Sequence Detail

ID/Version

Q9JIA7 Q9DBH6 Q91VA9 (UniProt | EBI)

Last sequence update: 2002-03-27
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Sphingosine kinase 2 {ECO:0000305}; Short=SK 2; Short=SPK 2; EC=2.7.1.91 {ECO:0000269|PubMed:10751414, ECO:0000269|PubMed:16118219, ECO:0000269|PubMed:17346996};

Provider

SWISS-PROT

Sequence

Polypeptide 617 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Sphk2	sphingosine kinase 2	105	105	3	32

Sequence references in MGI

J:62994 Liu H, et al., Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform. J Biol Chem. 2000 Jun 30;275(26):19513-20
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:103755 Mizugishi K, et al., Essential role for sphingosine kinases in neural and vascular development. Mol Cell Biol. 2005 Dec;25(24):11113-21
J:120074 Olivera A, et al., The sphingosine kinase-sphingosine-1-phosphate axis is a determinant of mast cell function and anaphylaxis. Immunity. 2007 Mar;26(3):287-97
J:221807 Sivasubramanian M, et al., Sphingosine kinase 2 and sphingosine-1-phosphate promotes mitochondrial function in dopaminergic neurons of mouse model of Parkinson's disease and in MPP+ -treated MN9D cells in vitro. Neuroscience. 2015 Apr 2;290:636-48
J:270483 Ravichandran S, et al., Sphk2(-/-) mice are protected from obesity and insulin resistance. Biochim Biophys Acta Mol Basis Dis. 2019 Mar 1;1865(3):570-576
J:271700 Hisano Y, et al., The sphingosine 1-phosphate transporter, SPNS2, functions as a transporter of the phosphorylated form of the immunomodulating agent FTY720. J Biol Chem. 2011 Jan 21;286(3):1758-66
J:273514 Maceyka M, et al., SphK1 and SphK2, sphingosine kinase isoenzymes with opposing functions in sphingolipid metabolism. J Biol Chem. 2005 Nov 4;280(44):37118-29
J:273588 Strub GM, et al., Sphingosine-1-phosphate produced by sphingosine kinase 2 in mitochondria interacts with prohibitin 2 to regulate complex IV assembly and respiration. FASEB J. 2011 Feb;25(2):600-12
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89