Sequence Detail

ID/Version

Q9JI59 Q8CE95 Q8C5K9 A6X955 (UniProt | EBI)

Last sequence update: 2000-10-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Junctional adhesion molecule B; Short=JAM-B;AltName: Full=Junctional adhesion molecule 2 {ECO:0000303|PubMed:11036763}; Short=JAM-2 {ECO:0000303|PubMed:11036763};AltName: Full=Vascular endothelial junction-associated molecule

Provider

SWISS-PROT

Sequence

Polypeptide 298 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Jam2	junction adhesion molecule 2	20	114	4	299

Sequence references in MGI

J:62864 Palmeri D, et al., Vascular endothelial junction-associated molecule, a novel member of the immunoglobulin superfamily, is localized to intercellular boundaries of endothelial cells. J Biol Chem. 2000 Jun 23;275(25):19139-45
J:68971 Aurrand-Lions MA, et al., Cloning of JAM-2 and JAM-3: an emerging junctional adhesion molecular family?. Curr Top Microbiol Immunol. 2000;251:91-8
J:92665 Gliki G, et al., Spermatid differentiation requires the assembly of a cell polarity complex downstream of junctional adhesion molecule-C. Nature. 2004 Sep 16;431(7006):320-4
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:106527 Lamagna C, et al., Dual interaction of JAM-C with JAM-B and alpha(M)beta2 integrin: function in junctional complexes and leukocyte adhesion. Mol Biol Cell. 2005 Oct;16(10):4992-5003
J:178387 Arcangeli ML, et al., JAM-B regulates maintenance of hematopoietic stem cells in the bone marrow. Blood. 2011 Oct 27;118(17):4609-19
J:225263 Arcangeli ML, et al., Function of Jam-B/Jam-C interaction in homing and mobilization of human and mouse hematopoietic stem and progenitor cells. Stem Cells. 2014 Apr;32(4):1043-54
J:225453 Meguenani M, et al., Junctional adhesion molecule B interferes with angiogenic VEGF/VEGFR2 signaling. FASEB J. 2015 Aug;29(8):3411-25
J:230547 Zhang X, et al., Transforming growth factor-beta3 regulates cell junction restructuring via MAPK-mediated mRNA destabilization and Smad-dependent protein degradation of junctional adhesion molecule B (JAM-B). Biochim Biophys Acta. 2015 Jun;1849(6):601-11
J:240335 Redmond SA, et al., Somatodendritic Expression of JAM2 Inhibits Oligodendrocyte Myelination. Neuron. 2016 Aug 17;91(4):824-36
J:276411 Ludwig RJ, et al., Junctional adhesion molecule (JAM)-B supports lymphocyte rolling and adhesion through interaction with alpha4beta1 integrin. Immunology. 2009 Oct;128(2):196-205
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:303196 Schottlaender LV, et al., Bi-allelic JAM2 Variants Lead to Early-Onset Recessive Primary Familial Brain Calcification. Am J Hum Genet. 2020 Mar 5;106(3):412-421