Sequence Detail

ID/Version

Q9JHR7 (UniProt | EBI)

Last sequence update: 2000-10-01
Last annotation update: 2023-11-08

Sequence description from provider

RecName: Full=Insulin-degrading enzyme; EC=3.4.24.56 {ECO:0000269|PubMed:12732730, ECO:0000269|PubMed:24847884, ECO:0000269|PubMed:9830016};AltName: Full=Insulin protease; Short=Insulinase;AltName: Full=Insulysin {ECO:0000303|PubMed:127327

Provider

SWISS-PROT

Sequence

Polypeptide 1019 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ide	insulin degrading enzyme	87	102	3	60

Sequence references in MGI

J:82747 Farris W, et al., Insulin-degrading enzyme regulates the levels of insulin, amyloid beta -protein, and the beta -amyloid precursor protein intracellular domain in vivo. Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):4162-7
J:93056 Miller BC, et al., Amyloid-beta peptide levels in brain are inversely correlated with insulysin activity levels in vivo. Proc Natl Acad Sci U S A. 2003 May 13;100(10):6221-6
J:183929 Zhao Y, et al., Loss of mPer2 increases plasma insulin levels by enhanced glucose-stimulated insulin secretion and impaired insulin clearance in mice. FEBS Lett. 2012 May 7;586(9):1306-11
J:203468 Park J, et al., SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 Jun 27;50(6):919-30
J:213208 Maianti JP, et al., Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones. Nature. 2014 Jul 3;511(7507):94-8
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89