Sequence Detail

ID/Version

Q9JHG7 Q80V09 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; Short=PI3-kinase subunit gamma; Short=PI3K-gamma; Short=PI3Kgamma; Short=PtdIns-3-kinase subunit gamma; EC=2.7.1.137 {ECO

Provider

SWISS-PROT

Sequence

Polypeptide 1102 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Pik3cg	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	111	98	3	16

Sequence references in MGI

J:60347 Sasaki T, et al., Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration [see comments]. Science. 2000 Feb 11;287(5455):1040-6
J:60349 Hirsch E, et al., Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation [see comments]. Science. 2000 Feb 11;287(5455):1049-53
J:65490 Hirsch E, et al., Analysis of the murine phosphoinositide 3-kinase gamma gene. Gene. 2000 Oct 3;256(1-2):69-81
J:79151 Crackower MA, et al., Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways. Cell. 2002 Sep 20;110(6):737-49
J:91945 Patrucco E, et al., PI3Kgamma modulates the cardiac response to chronic pressure overload by distinct kinase-dependent and -independent effects. Cell. 2004 Aug 6;118(3):375-87
J:93121 Del Prete A, et al., Defective dendritic cell migration and activation of adaptive immunity in PI3Kgamma-deficient mice. EMBO J. 2004 Sep 1;23(17):3505-15
J:113237 Webb LM, et al., Cutting edge: T cell development requires the combined activities of the p110gamma and p110delta catalytic isoforms of phosphatidylinositol 3-kinase. J Immunol. 2005 Sep 1;175(5):2783-7
J:125348 Schoenwaelder SM, et al., Identification of a unique co-operative phosphoinositide 3-kinase signaling mechanism regulating integrin alpha IIb beta 3 adhesive function in platelets. J Biol Chem. 2007 Sep 28;282(39):28648-58
J:147569 Saudemont A, et al., p110gamma and p110delta isoforms of phosphoinositide 3-kinase differentially regulate natural killer cell migration in health and disease. Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5795-800
J:155302 Kurig B, et al., Ras is an indispensable coregulator of the class IB phosphoinositide 3-kinase p87/p110gamma. Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20312-7
J:172667 Perino A, et al., Integrating cardiac PIP3 and cAMP signaling through a PKA anchoring function of p110gamma. Mol Cell. 2011 Apr 8;42(1):84-95
J:177172 Gu C, et al., The EphA8 receptor regulates integrin activity through p110gamma phosphatidylinositol-3 kinase in a tyrosine kinase activity-independent manner. Mol Cell Biol. 2001 Jul;21(14):4579-97
J:186412 Suire S, et al., GPCR activation of Ras and PI3Kc in neutrophils depends on PLCb2/b3 and the RasGEF RasGRP4. EMBO J. 2012 Jul 18;31(14):3118-29
J:281173 Takeda AJ, et al., Human PI3Kgamma deficiency and its microbiota-dependent mouse model reveal immunodeficiency and tissue immunopathology. Nat Commun. 2019 Sep 25;10(1):4364