Sequence Detail

ID/Version

Q9JHE3 Q3UWP9 Q8BNP0 Q8R236 Q8BQN7 (UniProt | EBI)

Last sequence update: 2000-10-01
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=Neutral ceramidase {ECO:0000305}; Short=N-CDase; Short=NCDase; EC=3.5.1.- {ECO:0000269|PubMed:10652340}; EC=3.5.1.23 {ECO:0000269|PubMed:10652340, ECO:0000269|PubMed:10753931, ECO:0000269|PubMed:14557071, ECO:

Provider

SWISS-PROT

Sequence

Polypeptide 756 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Asah2	N-acylsphingosine amidohydrolase 2	50	98	4	4

Sequence references in MGI

J:61655 Tani M, et al., Molecular cloning of the full-length cDNA encoding mouse neutral ceramidase. A novel but highly conserved gene family of neutral/alkaline ceramidases. J Biol Chem. 2000 Apr 14;275(15):11229-34
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:102906 Tani M, et al., Involvement of neutral ceramidase in ceramide metabolism at the plasma membrane and in extracellular milieu. J Biol Chem. 2005 Nov 4;280(44):36592-600
J:110485 Kono M, et al., Neutral ceramidase encoded by the Asah2 gene is essential for the intestinal degradation of sphingolipids. J Biol Chem. 2006 Mar 17;281(11):7324-31
J:167693 Romiti E, et al., Localization of neutral ceramidase in caveolin-enriched light membranes of murine endothelial cells. FEBS Lett. 2001 Oct 5;506(2):163-8
J:269550 Novgorodov SA, et al., Novel pathway of ceramide production in mitochondria: thioesterase and neutral ceramidase produce ceramide from sphingosine and acyl-CoA. J Biol Chem. 2011 Jul 15;286(28):25352-62
J:269642 Romiti E, et al., Neutral ceramidase secreted by endothelial cells is released in part associated with caveolin-1. Arch Biochem Biophys. 2003 Sep 1;417(1):27-33
J:269646 Tani M, et al., Purification and characterization of a neutral ceramidase from mouse liver. A single protein catalyzes the reversible reaction in which ceramide is both hydrolyzed and synthesized. J Biol Chem. 2000 Feb 4;275(5):3462-8