Sequence Detail

ID/Version

Q9ET47 Q9QY27 Q80ZC3 Q80ZC1 Q80ZC0 A2AK06 B1AWP3 A2AK13 Q6GYS0 Q6GYS1 B1AWQ2 A2AK09 B1AWP6 Q80ZC2 (UniProt | EBI)

Last sequence update: 2008-05-20
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Espin;AltName: Full=Ectoplasmic specialization protein;

Provider

SWISS-PROT

Sequence

Polypeptide 871 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Espn	espin	27	101	3	15

Sequence references in MGI

J:53411 Zheng L, et al., The deaf jerker mouse has a mutation in the gene encoding the espin actin-bundling proteins of hair cell stereocilia and lacks espins. Cell. 2000 Aug 4;102(3):377-85
J:58991 Chen B, et al., Espin contains an additional actin-binding site in its N terminus and is a major actin-bundling protein of the Sertoli cell-spermatid ectoplasmic specialization junctional plaque. Mol Biol Cell. 1999 Dec;10(12):4327-39
J:107807 Loomis PA, et al., Targeted wild-type and jerker espins reveal a novel, WH2-domain-dependent way to make actin bundles in cells. J Cell Sci. 2006 Apr 15;119(Pt 8):1655-65
J:114105 Sekerkova G, et al., Espins are multifunctional actin cytoskeletal regulatory proteins in the microvilli of chemosensory and mechanosensory cells. J Neurosci. 2004 Jun 9;24(23):5445-56
J:182310 Merritt RC, et al., Myosin IIIB uses an actin-binding motif in its espin-1 cargo to reach the tips of actin protrusions. Curr Biol. 2012 Feb 21;22(4):320-5
J:226747 Sekerkova G, et al., Roles of the espin actin-bundling proteins in the morphogenesis and stabilization of hair cell stereocilia revealed in CBA/CaJ congenic jerker mice. PLoS Genet. 2011 Mar;7(3):e1002032
J:229975 Liu H, et al., Myosin III-mediated cross-linking and stimulation of actin bundling activity of Espin. Elife. 2016;5:e12856
J:230827 Lelli A, et al., Class III myosins shape the auditory hair bundles by limiting microvilli and stereocilia growth. J Cell Biol. 2016 Jan 18;212(2):231-44
J:236347 Ebrahim S, et al., Stereocilia-staircase spacing is influenced by myosin III motors and their cargos espin-1 and espin-like. Nat Commun. 2016 Mar 01;7:10833
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89