Sequence Detail

ID/Version

Q9ESU6 Q8VHF8 B0V2V7 Q8VHF7 (UniProt | EBI)

Last sequence update: 2013-07-24
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Bromodomain-containing protein 4;AltName: Full=Mitotic chromosome-associated protein; Short=MCAP;

Provider

SWISS-PROT

Sequence

Polypeptide 1400 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Brd4	bromodomain containing 4	73	112	3	167

Sequence references in MGI

J:63928 Dey A, et al., A bromodomain protein, MCAP, associates with mitotic chromosomes and affects G(2)-to-M transition. Mol Cell Biol. 2000 Sep;20(17):6537-49
J:76662 Houzelstein D, et al., Growth and early postimplantation defects in mice deficient for the bromodomain-containing protein Brd4. Mol Cell Biol. 2002 Jun;22(11):3794-802
J:101015 Jang MK, et al., The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription. Mol Cell. 2005 Aug 19;19(4):523-34
J:203468 Park J, et al., SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 Jun 27;50(6):919-30
J:251939 Cheung KL, et al., Distinct Roles of Brd2 and Brd4 in Potentiating the Transcriptional Program for Th17 Cell Differentiation. Mol Cell. 2017 Mar 16;65(6):1068-1080.e5
J:266339 Olley G, et al., BRD4 interacts with NIPBL and BRD4 is mutated in a Cornelia de Lange-like syndrome. Nat Genet. 2018 Mar;50(3):329-332