Sequence Detail

ID/Version

Q9ESN6 Q3UHP5 Q8C981 Q5DU27 (UniProt | EBI)

Last sequence update: 2001-03-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Tripartite motif-containing protein 2; EC=2.3.2.27;AltName: Full=E3 ubiquitin-protein ligase TRIM2;AltName: Full=Neural activity-related RING finger protein;AltName: Full=RING-type E3 ubiquitin transferase TRIM2 {ECO:0000305};

Provider

SWISS-PROT

Sequence

Polypeptide 744 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Trim2	tripartite motif-containing 2	24	110	4	29

Sequence references in MGI

J:68594 Ohkawa N, et al., Molecular cloning and characterization of neural activity-related RING finger protein (NARF): a new member of the RBCC family is a candidate for the partner of myosin V. J Neurochem. 2001 Jul;78(1):75-87
J:69273 Reymond A, et al., The tripartite motif family identifies cell compartments. EMBO J. 2001 May 1;20(9):2140-51
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:140337 Balastik M, et al., Deficiency in ubiquitin ligase TRIM2 causes accumulation of neurofilament light chain and neurodegeneration. Proc Natl Acad Sci U S A. 2008 Aug 19;105(33):12016-21
J:177231 Thompson S, et al., Identification of a novel Bcl-2-interacting mediator of cell death (Bim) E3 ligase, tripartite motif-containing protein 2 (TRIM2), and its role in rapid ischemic tolerance-induced neuroprotection. J Biol Chem. 2011 Jun 3;286(22):19331-9
J:273377 Sarute N, et al., TRIM2, a novel member of the antiviral family, limits New World arenavirus entry. PLoS Biol. 2019 Feb;17(2):e3000137
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89