Sequence Detail

ID/Version

Q9ESL4 Q3V1X8 Q8BR73 Q9ESL3 (UniProt | EBI)

Last sequence update: 2001-03-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Mitogen-activated protein kinase kinase kinase 20; EC=2.7.11.25;AltName: Full=Leucine zipper- and sterile alpha motif kinase ZAK;AltName: Full=Leucine zipper- and sterile alpha motif-containing kinase;AltName: Full=MLK-like mitogen-a

Provider

SWISS-PROT

Sequence

Polypeptide 802 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Map3k20	mitogen-activated protein kinase kinase kinase 20	100	104	3	20

Sequence references in MGI

J:67266 Gotoh I, et al., Identification and characterization of a novel MAP kinase kinase kinase, MLTK. J Biol Chem. 2001 Feb 9;276(6):4276-86
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:231477 Spielmann M, et al., Exome sequencing and CRISPR/Cas genome editing identify mutations of ZAK as a cause of limb defects in humans and mice. Genome Res. 2016 Feb;26(2):183-91
J:241322 Jandhyala DM, et al., A Novel Zak Knockout Mouse with a Defective Ribotoxic Stress Response. Toxins (Basel). 2016 Sep 02;8(9)
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:328829 Vind AC, et al., ZAKalpha Recognizes Stalled Ribosomes through Partially Redundant Sensor Domains. Mol Cell. 2020 May 21;78(4):700-713.e7