Sequence Detail

ID/Version

Q9ES52 Q4U212 Q61173 Q9WUC2 Q61034 Q61181 Q9JKR7 Q9JLG0 Q9QVN8 Q3UPF9 Q9JLF9 (UniProt | EBI)

Last sequence update: 2007-09-11
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 {ECO:0000305}; EC=3.1.3.86 {ECO:0000269|PubMed:8643691, ECO:0000269|PubMed:8654924, ECO:0000269|PubMed:9341117};AltName: Full=Inositol polyphosphate-5-phosphatase D; EC

Provider

SWISS-PROT

Sequence

Polypeptide 1191 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Inpp5d	inositol polyphosphate-5-phosphatase D	57	101	3	54

Sequence references in MGI

J:35425 Chacko GW, et al., Negative signaling in B lymphocytes induces tyrosine phosphorylation of the 145-kDa inositol polyphosphate 5-phosphatase, SHIP. J Immunol. 1996 Sep 15;157(6):2234-8
J:37834 Liu Q, et al., Molecular cloning and chromosomal localization in human and mouse of the SH2-containing inositol phosphatase, INPP5D (SHIP). Amgen EST Program. Genomics. 1997 Jan 1;39(1):109-12
J:38189 Lioubin MN, et al., p150Ship, a signal transduction molecule with inositol polyphosphate-5-phosphatase activity. Genes Dev. 1996 May 1;10(9):1084-95
J:38190 Damen JE, et al., The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase. Proc Natl Acad Sci U S A. 1996 Feb 20;93(4):1689-93
J:39778 Liu L, et al., Interleukin-3 induces the association of the inositol 5-phosphatase SHIP with SHP2. J Biol Chem. 1997 Apr 25;272(17):10998-1001
J:41976 Ono M, et al., Deletion of SHIP or SHP-1 reveals two distinct pathways for inhibitory signaling. Cell. 1997 Jul 25;90(2):293-301
J:48193 Helgason CD, et al., Targeted disruption of SHIP leads to hemopoietic perturbations, lung pathology, and a shortened life span. Genes Dev. 1998 Jun 1;12(11):1610-20
J:51832 Huber M, et al., Targeted disruption of SHIP leads to Steel factor-induced degranulation of mast cells. EMBO J. 1998 Dec 15;17(24):7311-9
J:62950 Wolf I, et al., Cloning of the genomic locus of mouse SH2-containing Inositol 5-Phosphatase (SHIP) and a novel 110 kDa splice isoform SHIPdelta. Genomics. 2000;69(1):104-12
J:72115 Tu Z, et al., Embryonic and hematopoietic stem cells express a novel SH2-containing inositol 5'-phosphatase isoform that partners with the Grb2 adapter protein. Blood. 2001 Oct 1;98(7):2028-38
J:72477 Liu Q, et al., The inositol polyphosphate 5-phosphatase ship is a crucial negative regulator of B cell antigen receptor signaling. J Exp Med. 1998 Oct 5;188(7):1333-42
J:78771 Takeshita S, et al., SHIP-deficient mice are severely osteoporotic due to increased numbers of hyper-resorptive osteoclasts. Nat Med. 2002 Sep;8(9):943-9
J:91755 Maxwell MJ, et al., SHIP1 and Lyn Kinase Negatively Regulate Integrin alpha IIb beta 3 signaling in platelets. J Biol Chem. 2004 Jul 30;279(31):32196-204
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:113910 Sattler M, et al., SHIP1, an SH2 domain containing polyinositol-5-phosphatase, regulates migration through two critical tyrosine residues and forms a novel signaling complex with DOK1 and CRKL. J Biol Chem. 2001 Jan 26;276(4):2451-8
J:120426 Huber M, et al., The src homology 2-containing inositol phosphatase (SHIP) is the gatekeeper of mast cell degranulation. Proc Natl Acad Sci U S A. 1998 Sep 15;95(19):11330-5
J:124436 Cox D, et al., A regulatory role for Src homology 2 domain-containing inositol 5'-phosphatase (SHIP) in phagocytosis mediated by Fc gamma receptors and complement receptor 3 (alpha(M)beta(2); CD11b/CD18). J Exp Med. 2001 Jan 1;193(1):61-71
J:126426 Nishio M, et al., Control of cell polarity and motility by the PtdIns(3,4,5)P3 phosphatase SHIP1. Nat Cell Biol. 2007 Jan;9(1):36-44
J:127946 Lucas DM, et al., A novel spliced form of SH2-containing inositol phosphatase is expressed during myeloid development. Blood. 1999 Mar 15;93(6):1922-33
J:140846 Zhou P, et al., SHIP1 negatively regulates proliferation of osteoclast precursors via Akt-dependent alterations in D-type cyclins and p27. J Immunol. 2006 Dec 15;177(12):8777-84
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:161854 Hitomi K, et al., An immunoglobulin-like receptor, Allergin-1, inhibits immunoglobulin E-mediated immediate hypersensitivity reactions. Nat Immunol. 2010 Jul;11(7):601-7
J:188910 Morris SM, et al., Disabled-2 colocalizes with the LDLR in clathrin-coated pits and interacts with AP-2. Traffic. 2001 Feb;2(2):111-23
J:243541 Song M, et al., Inositol 5'-phosphatase, SHIP1 interacts with phospholipase C-gamma1 and modulates EGF-induced PLC activity. Exp Mol Med. 2005 Jun 30;37(3):161-8
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:297456 Rameh LE, et al., A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate. Nature. 1997 Nov 13;390(6656):192-6
J:308370 Baran CP, et al., The inositol 5'-phosphatase SHIP-1 and the Src kinase Lyn negatively regulate macrophage colony-stimulating factor-induced Akt activity. J Biol Chem. 2003 Oct 3;278(40):38628-36