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Sequence Detail
ID/Version
Q9ERI2 (UniProt | EBI) Last sequence update: 2001-03-01
Last annotation update: 2014-07-09
Sequence
description
from provider
RecName: Full=Ras-related protein Rab-27A;
Provider SWISS-PROT
Sequence
Polypeptide 221 aa
For this sequence
Source
Organism mouse
See UniProt | EBI for source
Annotated genes and markers Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.
Type Symbol Name GO Terms Expression
Assays
Orthologs Phenotypic
Alleles
Gene Rab27a RAB27A, member RAS oncogene family 59 2 5 158
Sequence references in MGI J:63231 Wilson SM, et al., A mutation in Rab27a causes the vesicle transport defects observed in ashen mice. Proc Natl Acad Sci U S A. 2000 Jul 5;97(14):7933-8
J:75312 Kuroda TS, et al., The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain. J Biol Chem. 2002 Mar 15;277(11):9212-8
J:75876 Wu XS, et al., Identification of an organelle receptor for myosin-Va. Nat Cell Biol. 2002 Apr;4(4):271-8
J:83108 Fukuda M, Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2. J Biol Chem. 2003 Apr 25;278(17):15373-80
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:116278 Saegusa C, et al., Decreased basal mucus secretion by Slp2-a-deficient gastric surface mucous cells. Genes Cells. 2006 Jun;11(6):623-31
J:133380 Higashio H, et al., Doc2{alpha} and Munc13-4 Regulate Ca2+-Dependent Secretory Lysosome Exocytosis in Mast Cells. J Immunol. 2008 Apr 1;180(7):4774-84
J:150917 Holt O, et al., Slp1 and Slp2-a localize to the plasma membrane of CTL and contribute to secretion from the immunological synapse. Traffic. 2008 Apr;9(4):446-57
J:155185 Chavas LM, et al., Elucidation of Rab27 recruitment by its effectors: structure of Rab27a bound to Exophilin4/Slp2-a. Structure. 2008 Oct 8;16(10):1468-77
J:169802 Kuroda TS, et al., Synaptotagmin-like protein 5: a novel Rab27A effector with C-terminal tandem C2 domains. Biochem Biophys Res Commun. 2002 May 10;293(3):899-906

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory