Sequence Detail

ID/Version

Q9EQZ6 Q9CW52 Q9Z1P0 Q8VIP9 (UniProt | EBI)

Last sequence update: 2001-03-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Rap guanine nucleotide exchange factor 4;AltName: Full=Exchange factor directly activated by cAMP 2;AltName: Full=Exchange protein directly activated by cAMP 2; Short=EPAC 2;AltName: Full=cAMP-dependent Rap1 guanine-nucleotide exchan

Provider

SWISS-PROT

Sequence

Polypeptide 1011 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Rapgef4	Rap guanine nucleotide exchange factor (GEF) 4	61	103	4	22

Sequence references in MGI

J:71886 Ozaki N, et al., cAMP-GEFII is a direct target of cAMP in regulated exocytosis. Nat Cell Biol. 2000 Nov;2(11):805-11
J:72605 Ueno H, et al., Characterization of the Gene EPAC2: Structure, Chromosomal Localization, Tissue Expression, and Identification of the Liver-Specific Isoform. Genomics. 2001 Nov;78(1/2):91-8
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:155189 Rehmann H, et al., Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B. Nature. 2008 Sep 4;455(7209):124-7