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Sequence Detail
Q9EQY0 Q9D340 (UniProt | EBI) Last sequence update: 2001-03-01
Last annotation update: 2019-12-11
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RecName: Full=Serine/threonine-protein kinase/endoribonuclease IRE1 {ECO:0000305};AltName: Full=Endoplasmic reticulum-to-nucleus signaling 1 {ECO:0000303|PubMed:11146108};AltName: Full=Inositol-requiring protein 1 {ECO:0000303|PubMed:11146108};AltName: Fu
Polypeptide 977 aa
For this sequence
Organism mouse
See UniProt | EBI for source
Annotated genes and markers Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.
Type Symbol Name GO Terms Expression
Orthologs Phenotypic
Gene Ern1 endoplasmic reticulum (ER) to nucleus signalling 1 81 76 9 23
Sequence references in MGI J:66969 Miyoshi K, et al., Characterization of mouse Ire1 alpha: cloning, mRNA localization in the brain and functional analysis in a neural cell line. Brain Res Mol Brain Res. 2000 Dec 28;85(1-2):68-76
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:107824 Lee K, et al., IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response. Genes Dev. 2002 Feb 15;16(4):452-66
J:136554 Luo D, et al., AIP1 is critical in transducing IRE1-mediated endoplasmic reticulum stress response. J Biol Chem. 2008 May 2;283(18):11905-12
J:255334 Sanches M, et al., Structure and mechanism of action of the hydroxy-aryl-aldehyde class of IRE1 endoribonuclease inhibitors. Nat Commun. 2014 Aug 28;5:4202

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory