Sequence Detail

ID/Version

Q9EQU3 Q4L0K4 Q99MF2 F8VPN5 Q4L0K3 Q99MQ8 (UniProt | EBI)

Last sequence update: 2011-12-14
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=Toll-like receptor 9;AltName: CD_antigen=CD289;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 1032 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Tlr9	toll-like receptor 9	111	103	3	29

Sequence references in MGI

J:66049 Hemmi H, et al., A Toll-like receptor recognizes bacterial DNA. Nature. 2000 Dec 7;408(6813):740-5
J:68228 Chuang TH, et al., Toll-like receptor 9 mediates CpG-DNA signaling. J Leukoc Biol. 2002 Mar;71(3):538-44
J:88906 Tabeta K, et al., Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection. Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3516-21
J:123483 Anderson AE, et al., TLR9 polymorphisms determine murine lymphocyte responses to Helicobacter: results from a genome-wide scan. Eur J Immunol. 2007 Jun;37(6):1548-61
J:132643 Kim YM, et al., UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes. Nature. 2008 Mar 13;452(7184):234-8
J:143338 Ewald SE, et al., The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor. Nature. 2008 Dec 4;456(7222):658-62
J:143561 Park B, et al., Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9. Nat Immunol. 2008 Dec;9(12):1407-14
J:161113 Brinkmann MM, et al., The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling. J Cell Biol. 2007 Apr 23;177(2):265-75
J:179457 Wu Y, et al., CMRF-35-like molecule 3 preferentially promotes TLR9-triggered proinflammatory cytokine production in macrophages by enhancing TNF receptor-associated factor 6 ubiquitination. J Immunol. 2011 Nov 1;187(9):4881-9
J:224870 Heinz LX, et al., The Lipid-Modifying Enzyme SMPDL3B Negatively Regulates Innate Immunity. Cell Rep. 2015 Jun 30;11(12):1919-28
J:240584 Ohto U, et al., Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9. Nature. 2015 Apr 30;520(7549):702-5
J:240588 Ewald SE, et al., Nucleic acid recognition by Toll-like receptors is coupled to stepwise processing by cathepsins and asparagine endopeptidase. J Exp Med. 2011 Apr 11;208(4):643-51
J:269559 Kimura T, et al., Endoplasmic Protein Nogo-B (RTN4-B) Interacts with GRAMD4 and Regulates TLR9-Mediated Innate Immune Responses. J Immunol. 2015 Jun 1;194(11):5426-36
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89