Sequence Detail

ID/Version

Q9EQN9 Q8R4Y1 Q8BRH5 (UniProt | EBI)

Last sequence update: 2001-03-01
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=Thiamine transporter 1 {ECO:0000303|PubMed:11481326}; Short=ThTr-1 {ECO:0000303|PubMed:11481326};AltName: Full=Solute carrier family 19 member 2 {ECO:0000305};

Provider

SWISS-PROT

Sequence

Polypeptide 498 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Slc19a2	solute carrier family 19 (thiamine transporter), member 2	21	98	3	12

Sequence references in MGI

J:72002 Fleming JC, et al., Characterization of a murine high-affinity thiamine transporter, slc19a2. Mol Genet Metab. 2001 Sep-Oct;74(1-2):273-80
J:72026 Lo PK, et al., Identification of a mouse thiamine transporter gene as a direct transcriptional target for p53. J Biol Chem. 2001 Oct 5;276(40):37186-93
J:77252 Lo PK, et al., Identification of transcriptional start sites and splicing of mouse thiamine transporter gene THTR-1 (Slc19a2). Biochim Biophys Acta. 2002 Jun 7;1576(1-2):209-13
J:79974 Oishi K, et al., Targeted disruption of Slc19a2, the gene encoding the high-affinity thiamin transporter Thtr-1, causes diabetes mellitus, sensorineural deafness and megaloblastosis in mice. Hum Mol Genet. 2002 Nov 1;11(23):2951-60
J:87410 Oishi K, et al., Male infertility due to germ cell apoptosis in mice lacking the thiamin carrier, Tht1. A new insight into the critical role of thiamin in spermatogenesis. Dev Biol. 2004 Feb 15;266(2):299-309
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:101675 Fleming JC, et al., Male infertility and thiamine-dependent erythroid hypoplasia in mice lacking thiamine transporter Slc19a2. Mol Genet Metab. 2003 Sep-Oct;80(1-2):234-41
J:118928 Liberman MC, et al., Deletion of SLC19A2, the high affinity thiamine transporter, causes selective inner hair cell loss and an auditory neuropathy phenotype. J Assoc Res Otolaryngol. 2006 Sep;7(3):211-7
J:183439 Subramanian VS, et al., Relative contribution of THTR-1 and THTR-2 in thiamin uptake by pancreatic acinar cells: studies utilizing Slc19a2 and Slc19a3 knockout mouse models. Am J Physiol Gastrointest Liver Physiol. 2012 Mar;302(5):G572-8
J:212164 Chen L, et al., OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin. Proc Natl Acad Sci U S A. 2014 Jul 8;111(27):9983-8
J:335672 Miyake K, et al., Identification of the amino acid residues involved in the species-dependent differences in the pyridoxine transport function of SLC19A3. J Biol Chem. 2022 Aug;298(8):102161
J:336071 Yamashiro T, et al., Animal species differences in the pyridoxine transport function of SLC19A3: Absence of Slc19a3-mediated pyridoxine uptake in the rat small intestine. Drug Metab Pharmacokinet. 2022 Jun;44:100456