Sequence Detail

ID/Version

Q9EQF4 B0FFS5 (UniProt | EBI)

Last sequence update: 2001-03-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Sperm-egg fusion protein Juno {ECO:0000305};AltName: Full=Folate receptor 4;AltName: Full=Folate receptor delta {ECO:0000303|PubMed:11111049}; Short=FR-delta {ECO:0000303|PubMed:11111049};AltName: Full=Folate-binding protein 3 {ECO:0

Provider

SWISS-PROT

Sequence

Polypeptide 244 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Izumo1r	IZUMO1 receptor, JUNO	10	100	3	10

Sequence references in MGI

J:66219 Spiegelstein O, et al., Identification of two putative novel folate receptor genes in humans and mouse. Gene. 2000 Nov 27;258(1-2):117-25
J:209568 Bianchi E, et al., Juno is the egg Izumo receptor and is essential for mammalian fertilization. Nature. 2014 Apr 24;508(7497):483-7
J:235303 Ohto U, et al., Structure of IZUMO1-JUNO reveals sperm-oocyte recognition during mammalian fertilization. Nature. 2016 Jun 23;534(7608):566-9
J:240828 Kato K, et al., Structural and functional insights into IZUMO1 recognition by JUNO in mammalian fertilization. Nat Commun. 2016 Jul 15;7:12198
J:289090 Lamas-Toranzo I, et al., TMEM95 is a sperm membrane protein essential for mammalian fertilization. Elife. 2020 Jun 2;9:e53913
J:333062 Brukman NG, et al., A novel function for the sperm adhesion protein IZUMO1 in cell-cell fusion. J Cell Biol. 2023 Feb 6;222(2)
J:359376 Chalbi M, et al., Binding of sperm protein Izumo1 and its egg receptor Juno drives Cd9 accumulation in the intercellular contact area prior to fusion during mammalian fertilization. Development. 2014 Oct;141(19):3732-9