Sequence Detail

ID/Version

Q9EQC4 Q8JZV3 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Very long chain fatty acid elongase 4 {ECO:0000255|HAMAP-Rule:MF_03204}; EC=2.3.1.199 {ECO:0000255|HAMAP-Rule:MF_03204, ECO:0000269|PubMed:18728184, ECO:0000269|PubMed:22158834, ECO:0000269|PubMed:22199362, ECO:0000269|PubMed:2347963

Provider

SWISS-PROT

Sequence

Polypeptide 312 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Elovl4	ELOVL fatty acid elongase 4	21	115	4	17

Sequence references in MGI

J:66736 Zhang K, et al., A 5-bp deletion in ELOVL4 is associated with two related forms of autosomal dominant macular dystrophy. Nat Genet. 2001 Jan;27(1):89-93
J:89293 Mandal MN, et al., Characterization of mouse orthologue of ELOVL4: genomic organization and spatial and temporal expression. Genomics. 2004 Apr;83(4):626-35
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:139131 Agbaga MP, et al., Role of Stargardt-3 macular dystrophy protein (ELOVL4) in the biosynthesis of very long chain fatty acids. Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):12843-8
J:194246 Barabas P, et al., Role of ELOVL4 and very long-chain polyunsaturated fatty acids in mouse models of Stargardt type 3 retinal degeneration. Proc Natl Acad Sci U S A. 2013 Mar 26;110(13):5181-6
J:208893 Logan S, et al., Endoplasmic reticulum microenvironment and conserved histidines govern ELOVL4 fatty acid elongase activity. J Lipid Res. 2014 Apr;55(4):698-708