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Sequence Detail
Q9EQ32 Q8BN25 Q3TC39 Q3U5J3 Q8C2Y4 Q3TBW6 Q2KHL6 (UniProt | EBI) Last sequence update: 2001-03-01
Last annotation update: 2020-06-17
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RecName: Full=Phosphoinositide 3-kinase adapter protein 1;AltName: Full=B-cell adapter for phosphoinositide 3-kinase;AltName: Full=B-cell phosphoinositide 3-kinase adapter protein 1;
Polypeptide 811 aa
For this sequence
Organism mouse
See UniProt | EBI for source
Annotated genes and markers Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.
Type Symbol Name GO Terms Expression
Orthologs Phenotypic
Gene Pik3ap1 phosphoinositide-3-kinase adaptor protein 1 22 70 9 7
Sequence references in MGI J:66479 Okada T, et al., BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation. Immunity. 2000 Dec;13(6):817-27
J:75075 Yamazaki T, et al., Essential immunoregulatory role for BCAP in B cell development and function. J Exp Med. 2002 Mar 4;195(5):535-45
J:84669 Yamazaki T, et al., Contribution of BCAP to maintenance of mature B cells through c-Rel. Nat Immunol. 2003 Aug;4(8):780-6
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:130759 Aiba Y, et al., Regulation of B-cell development by BCAP and CD19 through their binding to phosphoinositide 3-kinase. Blood. 2008 Feb 1;111(3):1497-503
J:137306 MacFarlane AW 4th, et al., Enhanced NK-cell development and function in BCAP-deficient mice. Blood. 2008 Jul 1;112(1):131-40
J:180126 Troutman TD, et al., Role for B-cell adapter for PI3K (BCAP) as a signaling adapter linking Toll-like receptors (TLRs) to serine/threonine kinases PI3K/Akt. Proc Natl Acad Sci U S A. 2012 Jan 3;109(1):273-8
J:180127 Ni M, et al., B-cell adaptor for PI3K (BCAP) negatively regulates Toll-like receptor signaling through activation of PI3K. Proc Natl Acad Sci U S A. 2012 Jan 3;109(1):267-72
J:196267 Matsumura T, et al., Identification of BCAP-(L) as a negative regulator of the TLR signaling-induced production of IL-6 and IL-10 in macrophages by tyrosine phosphoproteomics. Biochem Biophys Res Commun. 2010 Sep 17;400(2):265-70

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory