Sequence Detail

ID/Version

Q9EPR5 B2RSI4 B2RSI2 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=VPS10 domain-containing receptor SorCS2;Contains: RecName: Full=SorCS2 122 kDa chain {ECO:0000305|PubMed:22155786};Contains: RecName: Full=SorCS2 104 kDa chain {ECO:0000305|PubMed:22155786};Contains: RecName: Full=SorCS2 18 kDa chain {ECO

Provider

SWISS-PROT

Sequence

Polypeptide 1159 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Sorcs2	sortilin-related VPS10 domain containing receptor 2	32	105	3	28

Sequence references in MGI

J:67268 Rezgaoui M, et al., Identification of SorCS2, a novel member of the VPS10 domain containing receptor family, prominently expressed in the developing mouse brain. Mech Dev. 2001 Feb;100(2):335-8
J:214739 Glerup S, et al., SorCS2 regulates dopaminergic wiring and is processed into an apoptotic two-chain receptor in peripheral glia. Neuron. 2014 Jun 4;82(5):1074-87
J:242313 Forge A, et al., Disruption of SorCS2 reveals differences in the regulation of stereociliary bundle formation between hair cell types in the inner ear. PLoS Genet. 2017 Mar;13(3):e1006692
J:244563 Ma Q, et al., SorCS2-mediated NR2A trafficking regulates motor deficits in Huntington's disease. JCI Insight. 2017 May 04;2(9)
J:260288 Deinhardt K, et al., Neuronal growth cone retraction relies on proneurotrophin receptor signaling through Rac. Sci Signal. 2011 Dec 6;4(202):ra82
J:267910 Giza JI, et al., The BDNF Val66Met Prodomain Disassembles Dendritic Spines Altering Fear Extinction Circuitry and Behavior. Neuron. 2018 Jul 11;99(1):163-178.e6
J:274779 Malik AR, et al., SorCS2 Controls Functional Expression of Amino Acid Transporter EAAT3 and Protects Neurons from Oxidative Stress and Epilepsy-Induced Pathology. Cell Rep. 2019 Mar 5;26(10):2792-2804.e6
J:274852 Glerup S, et al., SorCS2 is required for BDNF-dependent plasticity in the hippocampus. Mol Psychiatry. 2016 Dec;21(12):1740-1751
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89