Sequence Detail

ID/Version

Q9EPK8 A0JNY0 Q9EQZ4 Q9ERZ7 Q9ES76 Q91XR5 (UniProt | EBI)

Last sequence update: 2001-03-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Transient receptor potential cation channel subfamily V member 4; Short=TrpV4;AltName: Full=Osm-9-like TRP channel 4; Short=OTRPC4;AltName: Full=Transient receptor potential protein 12; Short=TRP12;AltName: Full=Vanil

Provider

SWISS-PROT

Sequence

Polypeptide 871 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Trpv4	transient receptor potential cation channel, subfamily V, member 4	180	116	3	28

Sequence references in MGI

J:65451 Strotmann R, et al., OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity. Nat Cell Biol. 2000 Oct;2(10):695-702
J:65606 Liedtke W, et al., Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor. Cell. 2000 Oct 27;103(3):525-35
J:65973 Wissenbach U, et al., Trp12, a novel trp related protein from kidney. FEBS Lett. 2000 Nov 24;485(2-3):127-34
J:82577 Xu H, et al., Regulation of a transient receptor potential (TRP) channel by tyrosine phosphorylation. SRC family kinase-dependent tyrosine phosphorylation of TRPV4 on TYR-253 mediates its response to hypotonic stress. J Biol Chem. 2003 Mar 28;278(13):11520-7
J:84093 Suzuki M, et al., Impaired pressure sensation in mice lacking TRPV4. J Biol Chem. 2003 Jun 20;278(25):22664-8
J:87276 Suzuki M, et al., Microfilament-associated protein 7 increases the membrane expression of transient receptor potential vanilloid 4 (TRPV4). J Biol Chem. 2003 Dec 19;278(51):51448-53
J:113485 Liu X, et al., A role for AQP5 in activation of TRPV4 by hypotonicity: concerted involvement of AQP5 and TRPV4 in regulation of cell volume recovery. J Biol Chem. 2006 Jun 2;281(22):15485-95
J:114364 Cuajungco MP, et al., PACSINs bind to the TRPV4 cation channel. PACSIN 3 modulates the subcellular localization of TRPV4. J Biol Chem. 2006 Jul 7;281(27):18753-62
J:147227 Wegierski T, et al., Tyrosine phosphorylation modulates the activity of TRPV4 in response to defined stimuli. J Biol Chem. 2009 Jan 30;284(5):2923-33
J:162941 Sokabe T, et al., The TRPV4 channel contributes to intercellular junction formation in keratinocytes. J Biol Chem. 2010 Jun 11;285(24):18749-58
J:188264 Ye L, et al., TRPV4 Is a Regulator of Adipose Oxidative Metabolism, Inflammation, and Energy Homeostasis. Cell. 2012 Sep 28;151(1):96-110
J:196099 D'hoedt D, et al., Stimulus-specific modulation of the cation channel TRPV4 by PACSIN 3. J Biol Chem. 2008 Mar 7;283(10):6272-80
J:212044 Takayama Y, et al., Modulation of water efflux through functional interaction between TRPV4 and TMEM16A/anoctamin 1. FASEB J. 2014 May;28(5):2238-48
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:321482 Sakuta H, et al., Nax signaling evoked by an increase in [Na+] in CSF induces water intake via EET-mediated TRPV4 activation. Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R299-306