Sequence Detail

ID/Version

Q9EPA7 Q6B504 (UniProt | EBI)

Last sequence update: 2003-05-09
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 {ECO:0000305}; Short=NMN/NaMN adenylyltransferase 1; EC=2.7.7.1 {ECO:0000269|PubMed:15381699}; EC=2.7.7.18 {ECO:0000250|UniProtKB:Q9HAN9};AltName: Full=

Provider

SWISS-PROT

Sequence

Polypeptide 285 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Nmnat1	nicotinamide nucleotide adenylyltransferase 1	30	99	3	33

Sequence references in MGI

J:65178 Conforti L, et al., A Ufd2/D4Cole1e chimeric protein and overexpression of rbp7 in the slow wallerian degeneration (WldS) mouse. Proc Natl Acad Sci U S A. 2000 Oct 10;97(21):11377-82
J:92423 Araki T, et al., Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration. Science. 2004 Aug 13;305(5686):1010-3
J:94904 Revollo JR, et al., The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells. J Biol Chem. 2004 Dec 3;279(49):50754-63
J:111688 Sasaki Y, et al., Stimulation of nicotinamide adenine dinucleotide biosynthetic pathways delays axonal degeneration after axotomy. J Neurosci. 2006 Aug 16;26(33):8484-91
J:269726 Sasaki Y, et al., NMNAT1 inhibits axon degeneration via blockade of SARM1-mediated NAD(+) depletion. Elife. 2016 Oct 13;5:e19749
J:297184 Huang D, et al., Functional Interplay between Histone H2B ADP-Ribosylation and Phosphorylation Controls Adipogenesis. Mol Cell. 2020 Sep 17;79(6):934-949.e14