Sequence Detail

ID/Version

Q9DCS3 Q99L39 (UniProt | EBI)

Last sequence update: 2005-04-26
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Enoyl-[acyl-carrier-protein] reductase, mitochondrial; EC=1.3.1.104 {ECO:0000250|UniProtKB:Q9BV79};AltName: Full=2-enoyl thioester reductase;AltName: Full=Nuclear receptor-binding factor 1; Short=NRBF-1;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 373 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Mecr	mitochondrial trans-2-enoyl-CoA reductase	28	97	3	18

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:196142 Rardin MJ, et al., Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways. Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6
J:203468 Park J, et al., SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 Jun 27;50(6):919-30
J:242847 Nair RR, et al., Genetic modifications of Mecr reveal a role for mitochondrial 2-enoyl-CoA/ACP reductase in placental development in mice. Hum Mol Genet. 2017 Jun 01;26(11):2104-2117
J:267288 Nair RR, et al., Impaired Mitochondrial Fatty Acid Synthesis Leads to Neurodegeneration in Mice. J Neurosci. 2018 Nov 7;38(45):9781-9800
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89