Sequence Detail

ID/Version

Q9DBY1 Q8CGB5 Q80T88 (UniProt | EBI)

Last sequence update: 2007-03-20
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=E3 ubiquitin-protein ligase synoviolin; EC=2.3.2.27 {ECO:0000269|PubMed:29907570, ECO:0000269|PubMed:30389664};AltName: Full=RING-type E3 ubiquitin transferase synoviolin {ECO:0000305};AltName: Full=Synovial apoptosis inhibitor 1;

Provider

SWISS-PROT

Sequence

Polypeptide 612 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Syvn1	synovial apoptosis inhibitor 1, synoviolin	51	98	3	14

Sequence references in MGI

J:83413 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2003 Feb 28;10(1):35-48
J:86009 Amano T, et al., Synoviolin/Hrd1, an E3 ubiquitin ligase, as a novel pathogenic factor for arthropathy. Genes Dev. 2003 Oct 1;17(19):2436-49
J:97254 Yagishita N, et al., Essential role of synoviolin in embryogenesis. J Biol Chem. 2005 Mar 4;280(9):7909-16
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:119960 Omura T, et al., A ubiquitin ligase HRD1 promotes the degradation of Pael receptor, a substrate of Parkin. J Neurochem. 2006 Dec;99(6):1456-69
J:178646 Tsuchiya Y, et al., Dual regulation of the transcriptional activity of Nrf1 by beta-TrCP- and Hrd1-dependent degradation mechanisms. Mol Cell Biol. 2011 Nov;31(22):4500-12
J:270482 Wei J, et al., HRD1-ERAD controls production of the hepatokine FGF21 through CREBH polyubiquitination. EMBO J. 2018 Nov 15;37(22)
J:270663 Yang Y, et al., The endoplasmic reticulum-resident E3 ubiquitin ligase Hrd1 controls a critical checkpoint in B cell development in mice. J Biol Chem. 2018 Aug 17;293(33):12934-12944
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89