Sequence Detail

ID/Version

Q9DA75 Q80ZW8 (UniProt | EBI)

Last sequence update: 2001-06-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Sodium-dependent lysophosphatidylcholine symporter 1 {ECO:0000305}; Short=NLS1; Short=Sodium-dependent LPC symporter 1;AltName: Full=Major facilitator superfamily domain-containing protein 2A; Short=Mfsd2a {ECO:000030

Provider

SWISS-PROT

Sequence

Polypeptide 534 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Mfsd2a	MFSD2 lysolipid transporter A, lysophospholipid	72	108	4	23

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:143949 Angers M, et al., Mfsd2a encodes a novel major facilitator superfamily domain-containing protein highly induced in brown adipose tissue during fasting and adaptive thermogenesis. Biochem J. 2008 Dec 15;416(3):347-55
J:194781 Berger JH, et al., Major facilitator superfamily domain-containing protein 2a (MFSD2A) has roles in body growth, motor function, and lipid metabolism. PLoS One. 2012;7(11):e50629
J:210587 Nguyen LN, et al., Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid. Nature. 2014 May 22;509(7501):503-6
J:210589 Ben-Zvi A, et al., Mfsd2a is critical for the formation and function of the blood-brain barrier. Nature. 2014 May 22;509(7501):507-11
J:231781 Guemez-Gamboa A, et al., Inactivating mutations in MFSD2A, required for omega-3 fatty acid transport in brain, cause a lethal microcephaly syndrome. Nat Genet. 2015 Jul;47(7):809-13
J:314394 Wood CAP, et al., Structure and mechanism of blood-brain-barrier lipid transporter MFSD2A. Nature. 2021 Aug;596(7872):444-448