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Sequence Detail
Q9D906 Q8K4Q5 Q3TCD9 (UniProt | EBI) Last sequence update: 2001-06-01
Last annotation update: 2019-07-31
from provider
RecName: Full=Ubiquitin-like modifier-activating enzyme ATG7;AltName: Full=ATG12-activating enzyme E1 ATG7;AltName: Full=Autophagy-related protein 7; Short=APG7-like; Short=mAGP7;AltName: Full=Ubiquitin-activating enzyme E1-like protein;
Polypeptide 698 aa
For this sequence
Organism mouse
See UniProt | EBI for source
Annotated genes and markers Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.
Type Symbol Name GO Terms Expression
Orthologs Phenotypic
Gene Atg7 autophagy related 7 93 4 9 30
Sequence references in MGI J:75687 Tanida I, et al., Murine Apg12p Has a Substrate Preference for Murine Apg7p over Three Apg8p Homologs. Biochem Biophys Res Commun. 2002 Mar 22;292(1):256-62
J:80842 Mizushima N, et al., Mouse Apg10 as an Apg12-conjugating enzyme: analysis by the conjugation-mediated yeast two-hybrid method. FEBS Lett. 2002 Dec 18;532(3):450-4
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:100199 Komatsu M, et al., Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J Cell Biol. 2005 May 9;169(3):425-34
J:124947 Komatsu M, et al., Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration. Proc Natl Acad Sci U S A. 2007 Sep 4;104(36):14489-94
J:150289 Zhang J, et al., Mitochondrial clearance is regulated by Atg7-dependent and -independent mechanisms during reticulocyte maturation. Blood. 2009 Jul 2;114(1):157-64
J:154591 Singh R, et al., Autophagy regulates adipose mass and differentiation in mice. J Clin Invest. 2009 Nov;119(11):3329-39
J:154736 Zhang Y, et al., Adipose-specific deletion of autophagy-related gene 7 (atg7) in mice reveals a role in adipogenesis. Proc Natl Acad Sci U S A. 2009 Nov 24;106(47):19860-5
J:164739 Radoshevich L, et al., ATG12 conjugation to ATG3 regulates mitochondrial homeostasis and cell death. Cell. 2010 Aug 20;142(4):590-600
J:176843 Mortensen M, et al., The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance. J Exp Med. 2011 Mar 14;208(3):455-67
J:183932 Lee IH, et al., Atg7 modulates p53 activity to regulate cell cycle and survival during metabolic stress. Science. 2012 Apr 13;336(6078):225-8
J:203423 Pampliega O, et al., Functional interaction between autophagy and ciliogenesis. Nature. 2013 Oct 10;502(7470):194-200
J:225011 Wittkopf N, et al., Lack of intestinal epithelial atg7 affects paneth cell granule formation but does not compromise immune homeostasis in the gut. Clin Dev Immunol. 2012;2012:278059
J:266073 Toledo M, et al., Autophagy Regulates the Liver Clock and Glucose Metabolism by Degrading CRY1. Cell Metab. 2018 Aug 7;28(2):268-281.e4

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory