Sequence Detail

ID/Version

Q9D8T2 Q3TBD9 (UniProt | EBI)

Last sequence update: 2001-06-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Gasdermin-D {ECO:0000303|PubMed:26611636};AltName: Full=Gasdermin domain-containing protein 1;Contains: RecName: Full=Gasdermin-D, N-terminal {ECO:0000305}; Short=GSDMD-NT {ECO:0000303|PubMed:27383986}; Short=mGSDMD-NTD

Provider

SWISS-PROT

Sequence

Polypeptide 487 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Gsdmd	gasdermin D	29	104	2	48

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:140319 Fujii T, et al., Gasdermin D (Gsdmd) is dispensable for mouse intestinal epithelium development. Genesis. 2008 Aug;46(8):418-23
J:226780 Kayagaki N, et al., Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling. Nature. 2015 Oct 29;526(7575):666-71
J:226781 Shi J, et al., Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death. Nature. 2015 Oct 29;526(7575):660-5
J:229325 He WT, et al., Gasdermin D is an executor of pyroptosis and required for interleukin-1beta secretion. Cell Res. 2015 Dec;25(12):1285-98
J:234332 Aglietti RA, et al., GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes. Proc Natl Acad Sci U S A. 2016 Jul 12;113(28):7858-63
J:235300 Liu X, et al., Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores. Nature. 2016 Jul 7;535(7610):153-8
J:259899 Evavold CL, et al., The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages. Immunity. 2018 Jan 16;48(1):35-44.e6
J:261341 Heilig R, et al., The Gasdermin-D pore acts as a conduit for IL-1beta secretion in mice. Eur J Immunol. 2018 Apr;48(4):584-592
J:265832 Lee BL, et al., Caspase-11 auto-proteolysis is crucial for noncanonical inflammasome activation. J Exp Med. 2018 Sep 3;215(9):2279-2288
J:267270 Sarhan J, et al., Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection. Proc Natl Acad Sci U S A. 2018 Nov 13;115(46):E10888-E10897
J:268622 Orning P, et al., Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death. Science. 2018 Nov 30;362(6418):1064-1069
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:296114 Liu Z, et al., Structures of the Gasdermin D C-Terminal Domains Reveal Mechanisms of Autoinhibition. Structure. 2018 May 1;26(5):778-784.e3
J:296118 Wang K, et al., Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis. Cell. 2020 Mar 5;180(5):941-955.e20
J:296122 Liu Z, et al., Caspase-1 Engages Full-Length Gasdermin D through Two Distinct Interfaces That Mediate Caspase Recruitment and Substrate Cleavage. Immunity. 2020 Jul 14;53(1):106-114.e5
J:296127 Humphries F, et al., Succination inactivates gasdermin D and blocks pyroptosis. Science. 2020 Sep 25;369(6511):1633-1637
J:316837 Evavold CL, et al., Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway. Cell. 2021 Aug 19;184(17):4495-4511.e19
J:319941 Xia S, et al., Gasdermin D pore structure reveals preferential release of mature interleukin-1. Nature. 2021 May;593(7860):607-611
J:326897 Nozaki K, et al., Caspase-7 activates ASM to repair gasdermin and perforin pores. Nature. 2022 Jun;606(7916):960-967
J:334741 Zhu F, et al., The orphan receptor Nur77 binds cytoplasmic LPS to activate the non-canonical NLRP3 inflammasome. Immunity. 2023 Apr 11;56(4):753-767.e8
J:338142 He K, et al., Gasdermin D licenses MHCII induction to maintain food tolerance in small intestine. Cell. 2023 Jul 6;186(14):3033-3048.e20
J:338168 Yamagishi R, et al., Gasdermin D-mediated release of IL-33 from senescent hepatic stellate cells promotes obesity-associated hepatocellular carcinoma. Sci Immunol. 2022 Jun 24;7(72):eabl7209
J:341429 Chen W, et al., Allergen protease-activated stress granule assembly and gasdermin D fragmentation control interleukin-33 secretion. Nat Immunol. 2022 Jul;23(7):1021-1030
J:349394 Fattinger SA, et al., Gasdermin D is the only Gasdermin that provides protection against acute Salmonella gut infection in mice. Proc Natl Acad Sci U S A. 2023 Nov 28;120(48):e2315503120
J:352411 Wei C, et al., Brain endothelial GSDMD activation mediates inflammatory BBB breakdown. Nature. 2024 May;629(8013):893-900
J:352412 Zhang N, et al., A palmitoylation-depalmitoylation relay spatiotemporally controls GSDMD activation in pyroptosis. Nat Cell Biol. 2024 May;26(5):757-769
J:352419 Balasubramanian A, et al., The palmitoylation of gasdermin D directs its membrane translocation and pore formation during pyroptosis. Sci Immunol. 2024 Apr 12;9(94):eadn1452
J:362850 Chai Q, et al., A bacterial phospholipid phosphatase inhibits host pyroptosis by hijacking ubiquitin. Science. 2022 Oct 14;378(6616):eabq0132