Sequence Detail

ID/Version

Q9D8H7 Q3UWN9 (UniProt | EBI)

Last sequence update: 2001-06-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Metalloendopeptidase OMA1, mitochondrial {ECO:0000305}; EC=3.4.24.- {ECO:0000269|PubMed:20038678, ECO:0000269|PubMed:24550258, ECO:0000269|PubMed:24719224};AltName: Full=Overlapping with the m-AAA protease 1 homolog {ECO:0000303|PubM

Provider

SWISS-PROT

Sequence

Polypeptide 521 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Oma1	OMA1 zinc metallopeptidase	66	99	3	14

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:156874 Ehses S, et al., Regulation of OPA1 processing and mitochondrial fusion by m-AAA protease isoenzymes and OMA1. J Cell Biol. 2009 Dec 28;187(7):1023-36
J:184716 Quiros PM, et al., Loss of mitochondrial protease OMA1 alters processing of the GTPase OPA1 and causes obesity and defective thermogenesis in mice. EMBO J. 2012 May 2;31(9):2117-33
J:208034 Baker MJ, et al., Stress-induced OMA1 activation and autocatalytic turnover regulate OPA1-dependent mitochondrial dynamics. EMBO J. 2014 Mar 18;33(6):578-93
J:215813 Anand R, et al., The i-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission. J Cell Biol. 2014 Mar 17;204(6):919-29
J:229455 Wai T, et al., Imbalanced OPA1 processing and mitochondrial fragmentation cause heart failure in mice. Science. 2015 Dec 4;350(6265):aad0116
J:230824 Korwitz A, et al., Loss of OMA1 delays neurodegeneration by preventing stress-induced OPA1 processing in mitochondria. J Cell Biol. 2016 Jan 18;212(2):157-66
J:260499 Acin-Perez R, et al., Ablation of the stress protease OMA1 protects against heart failure in mice. Sci Transl Med. 2018 Mar 28;10(434)
J:289068 Zhang K, et al., Membrane depolarization activates the mitochondrial protease OMA1 by stimulating self-cleavage. EMBO Rep. 2014 May;15(5):576-85
J:289449 Bohovych I, et al., Metalloprotease OMA1 Fine-tunes Mitochondrial Bioenergetic Function and Respiratory Supercomplex Stability. Sci Rep. 2015 Sep 14;5:13989
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:347149 Murata D, et al., Mitochondrial Safeguard: a stress response that offsets extreme fusion and protects respiratory function via flickering-induced Oma1 activation. EMBO J. 2020 Dec 15;39(24):e105074