Sequence Detail

ID/Version

Q9D892 Q8R0Q8 (UniProt | EBI)

Last sequence update: 2003-04-23
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Inosine triphosphate pyrophosphatase {ECO:0000255|HAMAP-Rule:MF_03148}; Short=ITPase {ECO:0000255|HAMAP-Rule:MF_03148}; Short=Inosine triphosphatase {ECO:0000255|HAMAP-Rule:MF_03148}; EC=3.6.1.9 {ECO:0000255|HAMAP-Rul

Provider

SWISS-PROT

Sequence

Polypeptide 198 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Itpa	inosine triphosphatase (nucleoside triphosphate pyrophosphatase)	34	98	3	34

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:120973 Burgis NE, et al., Substrate specificity of RdgB protein, a deoxyribonucleoside triphosphate pyrophosphohydrolase. J Biol Chem. 2007 Feb 9;282(6):3531-8
J:166567 Sakumi K, et al., ITPA protein, an enzyme that eliminates deaminated purine nucleoside triphosphates in cells. Mutat Res. 2010 Nov 28;703(1):43-50
J:173150 Abolhassani N, et al., NUDT16 and ITPA play a dual protective role in maintaining chromosome stability and cell growth by eliminating dIDP/IDP and dITP/ITP from nucleotide pools in mammals. Nucleic Acids Res. 2010 May;38(9):2891-903
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89