Sequence Detail

ID/Version

Q9D666 D3Z0V9 Q3TV96 Q3TIW3 Q80SU8 Q99P23 Q6B4H0 Q8BZ99 (UniProt | EBI)

Last sequence update: 2004-02-02
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=SUN domain-containing protein 1 {ECO:0000305};AltName: Full=Protein unc-84 homolog A;AltName: Full=Sad1/unc-84 protein-like 1;

Provider

SWISS-PROT

Sequence

Polypeptide 913 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Sun1	Sad1 and UNC84 domain containing 1	50	98	4	33

Sequence references in MGI

J:76035 Bray JD, et al., Identification and Characterization of cDNAs Encoding Four Novel Proteins that Interact with Translin Associated Factor-X. Genomics. 2002 Jun;79(6):799-808
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:104409 Crisp M, et al., Coupling of the nucleus and cytoplasm: role of the LINC complex. J Cell Biol. 2006 Jan 2;172(1):41-53
J:109072 Haque F, et al., SUN1 interacts with nuclear lamin A and cytoplasmic nesprins to provide a physical connection between the nuclear lamina and the cytoskeleton. Mol Cell Biol. 2006 May;26(10):3738-51
J:122602 Ding X, et al., SUN1 is required for telomere attachment to nuclear envelope and gametogenesis in mice. Dev Cell. 2007 Jun;12(6):863-72
J:143409 Lu W, et al., Sun1 forms immobile macromolecular assemblies at the nuclear envelope. Biochim Biophys Acta. 2008 Dec;1783(12):2415-26
J:146636 Chi YH, et al., Requirement for Sun1 in the expression of meiotic reproductive genes and piRNA. Development. 2009 Mar;136(6):965-73
J:150047 Lei K, et al., SUN1 and SUN2 play critical but partially redundant roles in anchoring nuclei in skeletal muscle cells in mice. Proc Natl Acad Sci U S A. 2009 Jun 23;106(25):10207-12
J:153803 Adelfalk C, et al., Cohesin SMC1beta protects telomeres in meiocytes. J Cell Biol. 2009 Oct 19;187(2):185-99
J:154595 Ostlund C, et al., Dynamics and molecular interactions of linker of nucleoskeleton and cytoskeleton (LINC) complex proteins. J Cell Sci. 2009 Nov 15;122(Pt 22):4099-108
J:155113 Zhang X, et al., SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice. Neuron. 2009 Oct 29;64(2):173-87
J:159127 Haque F, et al., Mammalian SUN protein interaction networks at the inner nuclear membrane and their role in laminopathy disease processes. J Biol Chem. 2010 Jan 29;285(5):3487-98
J:163755 Gob E, et al., Mammalian sperm head formation involves different polarization of two novel LINC complexes. PLoS One. 2010;5(8):e12072
J:190404 Morimoto A, et al., A conserved KASH domain protein associates with telomeres, SUN1, and dynactin during mammalian meiosis. J Cell Biol. 2012 Jul 23;198(2):165-72
J:194486 Horn HF, et al., The LINC complex is essential for hearing. J Clin Invest. 2013 Feb;123(2):740-50
J:201813 Horn HF, et al., A mammalian KASH domain protein coupling meiotic chromosomes to the cytoskeleton. J Cell Biol. 2013 Sep 30;202(7):1023-39
J:205574 Shibuya H, et al., The TRF1-binding protein TERB1 promotes chromosome movement and telomere rigidity in meiosis. Nat Cell Biol. 2014 Feb;16(2):145-56
J:228378 Lee CY, et al., Mechanism and regulation of rapid telomere prophase movements in mouse meiotic chromosomes. Cell Rep. 2015 Apr 28;11(4):551-63
J:231308 Luo Y, et al., Depletion of the LINC complex disrupts cytoskeleton dynamics and meiotic resumption in mouse oocytes. Sci Rep. 2016;6:20408
J:287130 Kozono T, et al., Jaw1/LRMP has a role in maintaining nuclear shape via interaction with SUN proteins. J Biochem. 2018 Oct 1;164(4):303-311
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89