Sequence Detail

ID/Version

Q9D4B1 Q149I0 (UniProt | EBI)

Last sequence update: 2003-03-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Phosphatidylcholine:ceramide cholinephosphotransferase 2; EC=2.7.8.27 {ECO:0000269|PubMed:22580896};AltName: Full=Sphingomyelin synthase 2; Short=Sms2;

Provider

SWISS-PROT

Sequence

Polypeptide 365 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Sgms2	sphingomyelin synthase 2	48	104	4	10

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:105120 Huitema K, et al., Identification of a family of animal sphingomyelin synthases. EMBO J. 2004 Jan 14;23(1):33-44
J:164932 Liu J, et al., Macrophage sphingomyelin synthase 2 deficiency decreases atherosclerosis in mice. Circ Res. 2009 Jul 31;105(3):295-303
J:178175 Li Z, et al., Reducing plasma membrane sphingomyelin increases insulin sensitivity. Mol Cell Biol. 2011 Oct;31(20):4205-18
J:201497 Li Z, et al., Impact of sphingomyelin synthase 1 deficiency on sphingolipid metabolism and atherosclerosis in mice. Arterioscler Thromb Vasc Biol. 2012 Jul;32(7):1577-84
J:220024 Ding T, et al., All members in the sphingomyelin synthase gene family have ceramide phosphoethanolamine synthase activity. J Lipid Res. 2015 Mar;56(3):537-45