Sequence Detail

ID/Version

Q9D439 Q4KL15 (UniProt | EBI)

Last sequence update: 2006-11-28
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Cilia- and flagella-associated protein 53 {ECO:0000312|MGI:MGI:1921703};AltName: Full=Coiled-coil domain-containing protein 11 {ECO:0000312|MGI:MGI:1921703};

Provider

SWISS-PROT

Sequence

Polypeptide 514 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Cfap53	cilia and flagella associated protein 53	52	96	3	11

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:301033 Ide T, et al., CFAP53 regulates mammalian cilia-type motility patterns through differential localization and recruitment of axonemal dynein components. PLoS Genet. 2020 Dec;16(12):e1009232
J:307591 Wu B, et al., Essential Role of CFAP53 in Sperm Flagellum Biogenesis. Front Cell Dev Biol. 2021;9:676910
J:325559 Zhang R, et al., CCDC38 is required for sperm flagellum biogenesis and male fertility in mice. Development. 2022 Jun 1;149(11):dev200516
J:338030 Zhou L, et al., Structures of sperm flagellar doublet microtubules expand the genetic spectrum of male infertility. Cell. 2023 Jun 22;186(13):2897-2910.e19
J:342625 Chen Z, et al., De novo protein identification in mammalian sperm using in situ cryoelectron tomography and AlphaFold2 docking. Cell. 2023 Nov 9;186(23):5041-5053.e19
J:352387 Tai L, et al., In-cell structural insight into the stability of sperm microtubule doublet. Cell Discov. 2023 Nov 21;9(1):116