Sequence Detail

ID/Version

Q9D411 A3QQQ9 A9P6P9 A3QQR0 A3QQR1 A9P6P7 Q9DA58 (UniProt | EBI)

Last sequence update: 2001-06-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Testis-specific serine/threonine-protein kinase 4 {ECO:0000303|PubMed:20729278}; Short=TSK-4 {ECO:0000305}; Short=TSSK-4 {ECO:0000303|PubMed:20729278}; Short=Testis-specific kinase 4 {ECO:0000305}; EC=2.7.11.1

Provider

SWISS-PROT

Sequence

Polypeptide 328 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Tssk4	testis-specific serine kinase 4	53	96	2	6

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:175334 Li Y, et al., Expression and localization of five members of the testis-specific serine kinase (Tssk) family in mouse and human sperm and testis. Mol Hum Reprod. 2011 Jan;17(1):42-56
J:263397 Wang X, et al., Testis-specific serine/threonine protein kinase 4 (Tssk4) phosphorylates Odf2 at Ser-76. Sci Rep. 2016 Mar 10;6:22861
J:263429 Fu G, et al., Phosphorylated testis-specific serine/threonine kinase 4 may phosphorylate Crem at Ser-117. Biosci Biotechnol Biochem. 2016 Jun;80(6):1088-94
J:263437 Jha KN, et al., Heat shock protein 90 functions to stabilize and activate the testis-specific serine/threonine kinases, a family of kinases essential for male fertility. J Biol Chem. 2013 Jun 7;288(23):16308-20
J:263443 Wang X, et al., Tssk4 is essential for maintaining the structural integrity of sperm flagellum. Mol Hum Reprod. 2015 Feb;21(2):136-45
J:263473 Wei Y, et al., Isolation and characterization of mouse testis specific serine/threonine kinase 5 possessing four alternatively spliced variants. J Biochem Mol Biol. 2007 Sep 30;40(5):749-56
J:263476 Wei Y, et al., Testis specific serine/threonine kinase 4 (Tssk4) maintains its kinase activity by phosphorylating itself at Thr-197. Mol Biol Rep. 2013 Jan;40(1):439-47