Sequence Detail

ID/Version

Q9D3F7 (UniProt | EBI)

Last sequence update: 2001-06-01
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=DNA damage-inducible transcript 4 protein;AltName: Full=Dexamethasone-induced gene 2 protein;AltName: Full=HIF-1 responsive protein RTP801;AltName: Full=Protein regulated in development and DNA damage response 1; Short=REDD-1;

Provider

SWISS-PROT

Sequence

Polypeptide 229 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ddit4	DNA-damage-inducible transcript 4	33	102	3	19

Sequence references in MGI

J:75451 Shoshani T, et al., Identification of a novel hypoxia-inducible factor 1-responsive gene, RTP801, involved in apoptosis. Mol Cell Biol. 2002 Apr;22(7):2283-93
J:87045 Wang Z, et al., Dexamethasone-induced gene 2 (dig2) is a novel pro-survival stress gene induced rapidly by diverse apoptotic signals. J Biol Chem. 2003 Jul 18;278(29):27053-8
J:93450 Brafman A, et al., Inhibition of oxygen-induced retinopathy in RTP801-deficient mice. Invest Ophthalmol Vis Sci. 2004 Nov;45(10):3796-805
J:99368 Sofer A, et al., Regulation of mTOR and Cell Growth in Response to Energy Stress by REDD1. Mol Cell Biol. 2005 Jul;25(14):5834-45
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:158772 Horak P, et al., Negative feedback control of HIF-1 through REDD1-regulated ROS suppresses tumorigenesis. Proc Natl Acad Sci U S A. 2010 Mar 9;107(10):4675-80
J:172815 Wolff NC, et al., Cell-type-dependent regulation of mTORC1 by REDD1 and the tumor suppressors TSC1/TSC2 and LKB1 in response to hypoxia. Mol Cell Biol. 2011 May;31(9):1870-84
J:178326 Vadysirisack DD, et al., Feedback control of p53 translation by REDD1 and mTORC1 limits the p53-dependent DNA damage response. Mol Cell Biol. 2011 Nov;31(21):4356-65