Sequence Detail

ID/Version

Q9D074 Q3U5V9 Q8BZM9 Q3UDA1 Q6ZQ97 (UniProt | EBI)

Last sequence update: 2003-03-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=E3 ubiquitin-protein ligase MGRN1; EC=2.3.2.27;AltName: Full=Mahogunin RING finger protein 1;AltName: Full=RING-type E3 ubiquitin transferase MGRN1 {ECO:0000305};

Provider

SWISS-PROT

Sequence

Polypeptide 532 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Mgrn1	mahogunin, ring finger 1	59	101	4	49

Sequence references in MGI

J:80182 Phan LK, et al., The mouse mahoganoid coat color mutation disrupts a novel C3HC4 RING domain protein. J Clin Invest. 2002 Nov;110(10):1449-59
J:81466 He L, et al., Spongiform degeneration in mahoganoid mutant mice. Science. 2003 Jan 31;299(5607):710-2
J:86686 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2003 Aug 31;10(4):167-80
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:116645 Cota CD, et al., Mice with mutations in Mahogunin ring finger-1 (Mgrn1) exhibit abnormal patterning of the left-right axis. Dev Dyn. 2006 Dec;235(12):3438-47
J:119125 Bagher P, et al., Characterization of Mahogunin Ring Finger-1 expression in mice. Pigment Cell Res. 2006 Dec;19(6):635-43
J:129981 Sun K, et al., Mitochondrial dysfunction precedes neurodegeneration in mahogunin (Mgrn1) mutant mice. Neurobiol Aging. 2007 Dec;28(12):1840-52
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:152730 Chakrabarti O, et al., Functional depletion of mahogunin by cytosolically exposed prion protein contributes to neurodegeneration. Cell. 2009 Jun 12;137(6):1136-47
J:152824 Jiao J, et al., Transgenic analysis of the physiological functions of Mahogunin Ring Finger-1 isoforms. Genesis. 2009 Aug;47(8):524-34
J:164849 Jiao J, et al., Abnormal regulation of TSG101 in mice with spongiform neurodegeneration. Biochim Biophys Acta. 2009 Oct;1792(10):1027-35
J:253667 Pusapati GV, et al., CRISPR Screens Uncover Genes that Regulate Target Cell Sensitivity to the Morphogen Sonic Hedgehog. Dev Cell. 2018 Jan 8;44(1):113-129.e8
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89