Sequence Detail

ID/Version

Q9CZX0 Q8C2K2 Q8R369 (UniProt | EBI)

Last sequence update: 2001-06-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Elongator complex protein 3 {ECO:0000303|PubMed:19185337}; EC=2.3.1.311 {ECO:0000250|UniProtKB:D5VRB9};AltName: Full=tRNA uridine(34) acetyltransferase {ECO:0000305};

Provider

SWISS-PROT

Sequence

Polypeptide 547 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Elp3	elongator acetyltransferase complex subunit 3	46	100	3	17

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:150477 Creppe C, et al., Elongator controls the migration and differentiation of cortical neurons through acetylation of alpha-tubulin. Cell. 2009 Feb 6;136(3):551-64
J:187591 Close P, et al., DERP6 (ELP5) and C3ORF75 (ELP6) Regulate Tumorigenicity and Migration of Melanoma Cells as Subunits of Elongator. J Biol Chem. 2012 Sep 21;287(39):32535-45
J:238986 Yoo H, et al., Indispensable role for mouse ELP3 in embryonic stem cell maintenance and early development. Biochem Biophys Res Commun. 2016 Sep 16;478(2):631-6
J:258732 Bento-Abreu A, et al., Elongator subunit 3 (ELP3) modifies ALS through tRNA modification. Hum Mol Genet. 2018 Apr 1;27(7):1276-1289
J:273516 Laguesse S, et al., Loss of Elp3 Impairs the Acetylation and Distribution of Connexin-43 in the Developing Cerebral Cortex. Front Cell Neurosci. 2017;11:122
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89