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Sequence Detail
ID/Version
Q9CZN7 Q99K87 Q3TFD0 (UniProt | EBI) Last sequence update: 2001-06-01
Last annotation update: 2019-12-11
Sequence
description
from provider
RecName: Full=Serine hydroxymethyltransferase, mitochondrial {ECO:0000305}; Short=SHMT {ECO:0000305}; EC=2.1.2.1 {ECO:0000250|UniProtKB:P34897};AltName: Full=Glycine hydroxymethyltransferase {ECO:0000305};AltName: Full=Serine methylase {EC
Provider SWISS-PROT
Sequence
Polypeptide 504 aa
For this sequence
Source
Organism mouse
See UniProt | EBI for source
Annotated genes and markers Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.
Type Symbol Name GO Terms Expression
Assays
Orthologs Phenotypic
Alleles
Gene Shmt2 serine hydroxymethyltransferase 2 (mitochondrial) 66 6 8 14
Sequence references in MGI J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:203468 Park J, et al., SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 Jun 27;50(6):919-30
J:259137 Minton DR, et al., Serine Catabolism by SHMT2 Is Required for Proper Mitochondrial Translation Initiation and Maintenance of Formylmethionyl-tRNAs. Mol Cell. 2018 Feb 15;69(4):610-621.e5
J:259713 Tani H, et al., Mice deficient in the Shmt2 gene have mitochondrial respiration defects and are embryonic lethal. Sci Rep. 2018 Jan 11;8(1):425

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/21/2020
MGI 6.14
The Jackson Laboratory