Sequence Detail

ID/Version

Q9CZN7 Q3TFD0 Q99K87 (UniProt | EBI)

Last sequence update: 2001-06-01
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Serine hydroxymethyltransferase, mitochondrial {ECO:0000305}; Short=SHMT {ECO:0000305}; EC=2.1.2.1 {ECO:0000250|UniProtKB:P34897};AltName: Full=Glycine hydroxymethyltransferase {ECO:0000305};AltName: Full=Serine methylase {EC

Provider

SWISS-PROT

Sequence

Polypeptide 504 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Shmt2	serine hydroxymethyltransferase 2 (mitochondrial)	67	106	3	17

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:203468 Park J, et al., SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 Jun 27;50(6):919-30
J:259137 Minton DR, et al., Serine Catabolism by SHMT2 Is Required for Proper Mitochondrial Translation Initiation and Maintenance of Formylmethionyl-tRNAs. Mol Cell. 2018 Feb 15;69(4):610-621.e5
J:259713 Tani H, et al., Mice deficient in the Shmt2 gene have mitochondrial respiration defects and are embryonic lethal. Sci Rep. 2018 Jan 11;8(1):425
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89