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Sequence Detail
Q9CUS9 E9QP88 Q8R597 (UniProt | EBI) Last sequence update: 2011-07-27
Last annotation update: 2020-06-17
from provider
RecName: Full=Signal peptide peptidase-like 3 {ECO:0000250|UniProtKB:Q8TCT6}; Short=SPP-like 3 {ECO:0000250|UniProtKB:Q8TCT6}; EC=3.4.23.-;AltName: Full=Intramembrane protease 2 {ECO:0000250|UniProtKB:Q8TCT6}; Short=IMP-2 {ECO:0000
Polypeptide 384 aa
For this sequence
Organism mouse
See UniProt | EBI for source
Annotated genes and markers Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.
Type Symbol Name GO Terms Expression
Orthologs Phenotypic
Gene Sppl3 signal peptide peptidase 3 33 74 9 92
Sequence references in MGI J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:161922 Tang T, et al., A mouse knockout library for secreted and transmembrane proteins. Nat Biotechnol. 2010 Jul;28(7):749-55
J:216762 Voss M, et al., Shedding of glycan-modifying enzymes by signal peptide peptidase-like 3 (SPPL3) regulates cellular N-glycosylation. EMBO J. 2014 Dec 17;33(24):2890-905
J:221514 Makowski SL, et al., A protease-independent function for SPPL3 in NFAT activation. Mol Cell Biol. 2015 Jan;35(2):451-67
J:238258 Kuhn PH, et al., Secretome analysis identifies novel signal Peptide peptidase-like 3 (Sppl3) substrates and reveals a role of Sppl3 in multiple Golgi glycosylation pathways. Mol Cell Proteomics. 2015 Jun;14(6):1584-98

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory