Sequence Detail

ID/Version

Q99PJ1 F8VQ61 F6YP25 Q0ZM30 D6RCH0 Q0ZM20 F6XPA1 Q0ZM32 Q0ZM16 Q0ZM35 Q0ZM19 F6UPC9 F6KKG6 F7ASH0 Q0ZM25 Q3UTS7 F6U3Q6 F6WUN7 Q0ZM27 Q2VQG7 F7DFU0 Q0ZM33 F7CIN1 E9Q7D7 Q0ZM22 Q0ZM28 F6Y0A5 F7D5J8 Q0ZM18 Q0ZM21 E9Q7R2 Q0ZM23 Q0ZM29 Q0ZM15 F6R5Z7 F6VPR3 Q0ZM37 F6X715 Q0ZM34 Q0ZM31 F6RBV2 H3BKS0 Q0ZM24 Q3URZ1 E9Q7R1 Q0ZM26 F6KJX4 F6YZQ9 (UniProt | EBI)

Last sequence update: 2013-06-26
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Protocadherin-15;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 1943 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Pcdh15	protocadherin 15	80	102	4	29

Sequence references in MGI

J:66738 Alagramam KN, et al., The mouse ames waltzer hearing-loss mutant is caused by mutation of pcdh15, a novel protocadherin gene. Nat Genet. 2001 Jan;27(1):99-102
J:70588 Murcia CL, et al., Expression of Pcdh15 in the inner ear, nervous system and various epithelia of the developing embryo. Mech Dev. 2001 Jul;105(1-2):163-6
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:105750 Senften M, et al., Physical and functional interaction between protocadherin 15 and myosin VIIa in mechanosensory hair cells. J Neurosci. 2006 Feb 15;26(7):2060-71
J:112247 Haywood-Watson RJ 2nd, et al., Ames Waltzer deaf mice have reduced electroretinogram amplitudes and complex alternative splicing of Pcdh15 transcripts. Invest Ophthalmol Vis Sci. 2006 Jul;47(7):3074-84
J:125331 Kazmierczak P, et al., Cadherin 23 and protocadherin 15 interact to form tip-link filaments in sensory hair cells. Nature. 2007 Sep 6;449(7158):87-91
J:171218 Caberlotto E, et al., Usher type 1G protein sans is a critical component of the tip-link complex, a structure controlling actin polymerization in stereocilia. Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5825-30
J:192825 Sotomayor M, et al., Structure of a force-conveying cadherin bond essential for inner-ear mechanotransduction. Nature. 2012 Dec 6;492(7427):128-32
J:193334 Xiong W, et al., TMHS is an integral component of the mechanotransduction machinery of cochlear hair cells. Cell. 2012 Dec 7;151(6):1283-95
J:214830 Maeda R, et al., Tip-link protein protocadherin 15 interacts with transmembrane channel-like proteins TMC1 and TMC2. Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12907-12
J:217448 Zhao B, et al., TMIE is an essential component of the mechanotransduction machinery of cochlear hair cells. Neuron. 2014 Dec 3;84(5):954-67
J:249939 Cunningham CL, et al., The murine catecholamine methyltransferase mTOMT is essential for mechanotransduction by cochlear hair cells. Elife. 2017 May 15;6:e24318
J:349395 Lee JH, et al., The Piezo channel is a mechano-sensitive complex component in the mammalian inner ear hair cell. Nat Commun. 2024 Jan 16;15(1):526