Sequence Detail

ID/Version

Q99P72 Q8BH78 Q9CTE3 Q8BGM9 Q8K3G8 Q8BGK7 Q8BHF5 Q78NS1 Q80W95 Q5DTK9 Q8K290 Q7TNB7 (UniProt | EBI)

Last sequence update: 2006-05-02
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Reticulon-4 {ECO:0000305};AltName: Full=Neurite outgrowth inhibitor; Short=Nogo protein {ECO:0000303|PubMed:27786289};

Provider

SWISS-PROT

Sequence

Polypeptide 1162 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Rtn4	reticulon 4	122	120	4	125

Sequence references in MGI

J:75771 Hu WH, et al., Identification and characterization of a novel Nogo-interacting mitochondrial protein (NIMP). J Neurochem. 2002 Apr;81(1):36-45
J:81211 Oertle T, et al., Genomic Structure and Functional Characterisation of the Promoters of Human and Mouse nogo/rtn4. J Mol Biol. 2003 Jan 10;325(2):299-323
J:90093 Acevedo L, et al., A new role for Nogo as a regulator of vascular remodeling. Nat Med. 2004 Apr;10(4):382-8
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:153670 Yu J, et al., Reticulon 4B (Nogo-B) is necessary for macrophage infiltration and tissue repair. Proc Natl Acad Sci U S A. 2009 Oct 13;106(41):17511-6
J:161875 Mathis C, et al., Nogo-a regulates neural precursor migration in the embryonic mouse cortex. Cereb Cortex. 2010 Oct;20(10):2380-90
J:163856 Petrinovic MM, et al., Neuronal Nogo-A regulates neurite fasciculation, branching and extension in the developing nervous system. Development. 2010 Aug 1;137(15):2539-50
J:169605 Di Lorenzo A, et al., Endothelial reticulon-4B (Nogo-B) regulates ICAM-1-mediated leukocyte transmigration and acute inflammation. Blood. 2011 Feb 17;117(7):2284-95
J:187362 Munton RP, et al., Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations. Mol Cell Proteomics. 2007 Feb;6(2):283-93
J:197333 Walchli T, et al., Nogo-A is a negative regulator of CNS angiogenesis. Proc Natl Acad Sci U S A. 2013 May 21;110(21):E1943-52
J:228796 Cantalupo A, et al., Nogo-B regulates endothelial sphingolipid homeostasis to control vascular function and blood pressure. Nat Med. 2015 Sep;21(9):1028-37
J:263376 Trinidad JC, et al., Comprehensive identification of phosphorylation sites in postsynaptic density preparations. Mol Cell Proteomics. 2006 May;5(5):914-22
J:269544 Ramo O, et al., NOGO-A/RTN4A and NOGO-B/RTN4B are simultaneously expressed in epithelial, fibroblast and neuronal cells and maintain ER morphology. Sci Rep. 2016 Oct 27;6:35969
J:269555 Jia S, et al., Nogo-C regulates cardiomyocyte apoptosis during mouse myocardial infarction. Cell Death Dis. 2016 Oct 20;7(10):e2432
J:269559 Kimura T, et al., Endoplasmic Protein Nogo-B (RTN4-B) Interacts with GRAMD4 and Regulates TLR9-Mediated Innate Immune Responses. J Immunol. 2015 Jun 1;194(11):5426-36
J:271690 Gao L, et al., Reticulon 4B (Nogo-B) facilitates hepatocyte proliferation and liver regeneration in mice. Hepatology. 2013 May;57(5):1992-2003
J:286567 Lee SH, et al., REEP5 depletion causes sarco-endoplasmic reticulum vacuolization and cardiac functional defects. Nat Commun. 2020 Feb 19;11(1):965
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:331499 Kragness S, et al., An Rtn4/Nogo-A-interacting micropeptide modulates synaptic plasticity with age. PLoS One. 2022;17(6):e0269404