Sequence Detail

ID/Version

Q99NH2 Q58T11 Q58T10 Q8CB21 (UniProt | EBI)

Last sequence update: 2008-11-25
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Partitioning defective 3 homolog; Short=PAR-3; Short=PARD-3;AltName: Full=Atypical PKC isotype-specific-interacting protein; Short=ASIP;AltName: Full=Ephrin-interacting protein; Short=PHIP;

Provider

SWISS-PROT

Sequence

Polypeptide 1333 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Pard3	par-3 family cell polarity regulator	85	125	4	48

Sequence references in MGI

J:63704 Lin D, et al., A mammalian PAR-3-PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity. Nat Cell Biol. 2000 Aug;2(8):540-7
J:69174 Joberty G, et al., The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42. Nat Cell Biol. 2000 Aug;2(8):531-9
J:98299 Duncan FE, et al., PAR-3 defines a central subdomain of the cortical actin cap in mouse eggs. Dev Biol. 2005 Apr 1;280(1):38-47
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:156410 Terawaki S, et al., The PHCCEx domain of Tiam1/2 is a novel protein- and membrane-binding module. EMBO J. 2010 Jan 6;29(1):236-50
J:156525 Ikenouchi J, et al., FRMD4A regulates epithelial polarity by connecting Arf6 activation with the PAR complex. Proc Natl Acad Sci U S A. 2010 Jan 12;107(2):748-53
J:177468 Beirowski B, et al., Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signaling. Proc Natl Acad Sci U S A. 2011 Oct 25;108(43):E952-61
J:191149 Alves CH, et al., Loss of CRB2 in the mouse retina mimics human retinitis pigmentosa due to mutations in the CRB1 gene. Hum Mol Genet. 2013 Jan 1;22(1):35-50
J:200342 Lin D, et al., The carboxyl terminus of B class ephrins constitutes a PDZ domain binding motif. J Biol Chem. 1999 Feb 5;274(6):3726-33
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89