Sequence Detail

ID/Version

Q99MV5 Q7TPA9 Q8C3W0 Q924C2 (UniProt | EBI)

Last sequence update: 2001-06-01
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=RNA helicase Mov10l1 {ECO:0000305}; EC=3.6.4.13 {ECO:0000305|PubMed:25762440};AltName: Full=Cardiac helicase activated by MEF2 protein {ECO:0000303|PubMed:11397016};AltName: Full=Cardiac-specific RNA helicase {ECO:0000303|PubMed:1139

Provider

SWISS-PROT

Sequence

Polypeptide 1187 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Mov10l1	Mov10 like RISC complex RNA helicase 1	23	112	2	14

Sequence references in MGI

J:68614 Wang PJ, et al., An abundance of X-linked genes expressed in spermatogonia. Nat Genet. 2001 Apr;27(4):422-6
J:69957 Liu ZP, et al., CHAMP, a novel cardiac-specific helicase regulated by MEF2C. Dev Biol. 2001 Jun 15;234(2):497-509
J:84692 Ueyama T, et al., Csm, a cardiac-specific isoform of the RNA helicase Mov10l1, is regulated by Nkx2.5 in embryonic heart. J Biol Chem. 2003 Aug 1;278(31):28750-7
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:114019 Liu ZP, et al., Suppression of proliferation and cardiomyocyte hypertrophy by CHAMP, a cardiac-specific RNA helicase. Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):2043-8
J:161124 Frost RJ, et al., MOV10L1 is necessary for protection of spermatocytes against retrotransposons by Piwi-interacting RNAs. Proc Natl Acad Sci U S A. 2010 Jun 29;107(26):11847-52
J:161125 Zheng K, et al., Mouse MOV10L1 associates with Piwi proteins and is an essential component of the Piwi-interacting RNA (piRNA) pathway. Proc Natl Acad Sci U S A. 2010 Jun 29;107(26):11841-6
J:194084 Zheng K, et al., Blockade of pachytene piRNA biogenesis reveals a novel requirement for maintaining post-meiotic germline genome integrity. PLoS Genet. 2012;8(11):e1003038
J:221349 Vourekas A, et al., The RNA helicase MOV10L1 binds piRNA precursors to initiate piRNA processing. Genes Dev. 2015 Mar 15;29(6):617-29
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89