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Sequence Detail
ID/Version
Q99MQ3 Q91XU5 Q811I8 A2AM77 Q7TMZ3 (UniProt | EBI) Last sequence update: 2004-06-07
Last annotation update: 2019-10-16
Sequence
description
from provider
RecName: Full=Serine/threonine-protein kinase PINK1, mitochondrial; EC=2.7.11.1 {ECO:0000269|PubMed:24652937};AltName: Full=BRPK;AltName: Full=PTEN-induced putative kinase protein 1;Flags: Precursor;
Provider SWISS-PROT
Sequence
Polypeptide 580 aa
For this sequence
Source
Organism mouse
See UniProt | EBI for source
Annotated genes and markers Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.
Type Symbol Name GO Terms Expression
Assays
Orthologs Phenotypic
Alleles
Gene Pink1 PTEN induced putative kinase 1 122 5 9 16
Sequence references in MGI J:100301 Nakajima A, et al., BRPK, a novel protein kinase showing increased expression in mouse cancer cell lines with higher metastatic potential. Cancer Lett. 2003 Nov 25;201(2):195-201
J:140335 Gautier CA, et al., Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress. Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11364-9
J:146282 Xiong H, et al., Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation. J Clin Invest. 2009 Mar;119(3):650-60
J:209583 Morais VA, et al., PINK1 loss-of-function mutations affect mitochondrial complex I activity via NdufA10 ubiquinone uncoupling. Science. 2014 Apr 11;344(6180):203-7
J:211292 Koyano F, et al., Ubiquitin is phosphorylated by PINK1 to activate parkin. Nature. 2014 Jun 5;510(7503):162-6
J:225033 Morais VA, et al., Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function. EMBO Mol Med. 2009 May;1(2):99-111

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/12/2019
MGI 6.14
The Jackson Laboratory