Sequence Detail

ID/Version

Q99ML1 (UniProt | EBI)

Last sequence update: 2001-06-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Bcl-2-binding component 3;AltName: Full=p53 up-regulated modulator of apoptosis;

Provider

SWISS-PROT

Sequence

Polypeptide 193 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Bbc3	BCL2 binding component 3	66	123	3	28

Sequence references in MGI

J:76185 Yu J, et al., PUMA induces the rapid apoptosis of colorectal cancer cells. Mol Cell. 2001 Mar;7(3):673-82
J:167725 Galehdar Z, et al., Neuronal apoptosis induced by endoplasmic reticulum stress is regulated by ATF4-CHOP-mediated induction of the Bcl-2 homology 3-only member PUMA. J Neurosci. 2010 Dec 15;30(50):16938-48
J:168877 Day CL, et al., Structure of the BH3 domains from the p53-inducible BH3-only proteins Noxa and Puma in complex with Mcl-1. J Mol Biol. 2008 Jul 25;380(5):958-71
J:190239 Ghosh AP, et al., CHOP potentially co-operates with FOXO3a in neuronal cells to regulate PUMA and BIM expression in response to ER stress. PLoS One. 2012;7(6):e39586
J:247400 Smits C, et al., Structural plasticity underpins promiscuous binding of the prosurvival protein A1. Structure. 2008 May;16(5):818-29