Sequence Detail

ID/Version

Q99LI8 Q61691 Q8BQW3 (UniProt | EBI)

Last sequence update: 2005-07-19
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Hepatocyte growth factor-regulated tyrosine kinase substrate;

Provider

SWISS-PROT

Sequence

Polypeptide 775 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Hgs	HGF-regulated tyrosine kinase substrate	44	116	3	19

Sequence references in MGI

J:29402 Komada M, et al., Growth factor-induced tyrosine phosphorylation of Hrs, a novel 115-kilodalton protein with a structurally conserved putative zinc finger domain. Mol Cell Biol. 1995 Nov;15(11):6213-21
J:44869 Asao H, et al., Hrs is associated with STAM, a signal-transducing adaptor molecule. Its suppressive effect on cytokine-induced cell growth. J Biol Chem. 1997 Dec 26;272(52):32785-91
J:48347 Lu L, et al., Human Hrs, a tyrosine kinase substrate in growth factor-stimulated cells: cDNA cloning and mapping of the gene to chromosome 17. Gene. 1998 Jun 15;213(1-2):125-32
J:55580 Komada M, et al., Hrs, a FYVE finger protein localized to early endosomes, is implicated in vesicular traffic and required for ventral folding morphogenesis. Genes Dev. 1999 Jun 1;13(11):1475-85
J:65990 Miura S, et al., Hgs (Hrs), a FYVE domain protein, is involved in smad signaling through cooperation with SARA. Mol Cell Biol. 2000 Dec;20(24):9346-55
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:203468 Park J, et al., SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 Jun 27;50(6):919-30
J:220514 Regan-Klapisz E, et al., Ubiquilin recruits Eps15 into ubiquitin-rich cytoplasmic aggregates via a UIM-UBL interaction. J Cell Sci. 2005 Oct 1;118(Pt 19):4437-50
J:224743 Lu Q, et al., TSG101 interaction with HRS mediates endosomal trafficking and receptor down-regulation. Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7626-31
J:245341 Ren X, et al., Hybrid structural model of the complete human ESCRT-0 complex. Structure. 2009 Mar 11;17(3):406-16
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89