Sequence Detail

ID/Version

Q99LG4 Q3TTN5 Q3TZL6 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Tetratricopeptide repeat protein 5 {ECO:0000250|UniProtKB:Q8N0Z6}; Short=TPR repeat protein 5 {ECO:0000250|UniProtKB:Q8N0Z6};AltName: Full=Stress-responsive activator of p300 {ECO:0000303|PubMed:18833288}; Short=Protein Strap

Provider

SWISS-PROT

Sequence

Polypeptide 440 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ttc5	tetratricopeptide repeat domain 5	36	96	3	7

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:182131 Adams CJ, et al., The p53 cofactor Strap exhibits an unexpected TPR motif and oligonucleotide-binding (OB)-fold structure. Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):3778-83
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:314385 Adams CJ, et al., ATM and Chk2 kinase target the p53 cofactor Strap. EMBO Rep. 2008 Dec;9(12):1222-9
J:314386 Demonacos C, et al., A new effector pathway links ATM kinase with the DNA damage response. Nat Cell Biol. 2004 Oct;6(10):968-76
J:314387 Hu X, et al., LC3 and STRAP regulate actin filament assembly by JMY during autophagosome formation. J Cell Biol. 2019 Jan 7;218(1):251-266
J:314388 Maniam S, et al., Cofactor Strap regulates oxidative phosphorylation and mitochondrial p53 activity through ATP synthase. Cell Death Differ. 2015 Jan;22(1):156-63
J:314389 Jansson M, et al., Arginine methylation regulates the p53 response. Nat Cell Biol. 2008 Dec;10(12):1431-9
J:314390 Xu D, et al., A transcription cofactor required for the heat-shock response. EMBO Rep. 2008 Jul;9(7):662-9
J:314962 Demonacos C, et al., A TPR motif cofactor contributes to p300 activity in the p53 response. Mol Cell. 2001 Jul;8(1):71-84