Sequence Detail

ID/Version

Q99LD8 (UniProt | EBI)

Last sequence update: 2001-06-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Putative hydrolase DDAH2; EC=3.-.-.- {ECO:0000250|UniProtKB:O95865};AltName: Full=DDAHII;AltName: Full=Inactive N(G),N(G)-dimethylarginine dimethylaminohydrolase 2; Short=DDAH-2; Short=Inactive dimethylarginine dimeth

Provider

SWISS-PROT

Sequence

Polypeptide 285 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ddah2	DDAH family member 2, ADMA independent	9	99	3	12

Sequence references in MGI

J:182373 Hu X, et al., Dimethylarginine dimethylaminohydrolase-1 is the critical enzyme for degrading the cardiovascular risk factor asymmetrical dimethylarginine. Arterioscler Thromb Vasc Biol. 2011 Jul;31(7):1540-6
J:199962 Hasegawa K, et al., The hydrolase DDAH2 enhances pancreatic insulin secretion by transcriptional regulation of secretagogin through a Sirt1-dependent mechanism in mice. FASEB J. 2013 Jun;27(6):2301-15
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:337786 Ragavan VN, et al., A multicentric consortium study demonstrates that dimethylarginine dimethylaminohydrolase 2 is not a dimethylarginine dimethylaminohydrolase. Nat Commun. 2023 Jun 9;14(1):3392
J:362836 Huang S, et al., DDAH2 suppresses RLR-MAVS-mediated innate antiviral immunity by stimulating nitric oxide-activated, Drp1-induced mitochondrial fission. Sci Signal. 2021 Apr 13;14(678)