Sequence Detail

ID/Version

Q99JY8 Q3TVM4 Q3TXR7 Q8BTB7 (UniProt | EBI)

Last sequence update: 2001-06-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Phospholipid phosphatase 3 {ECO:0000305}; EC=3.1.3.- {ECO:0000269|PubMed:12925589, ECO:0000269|PubMed:21319224}; EC=3.1.3.4 {ECO:0000269|PubMed:12925589};AltName: Full=Lipid phosphate phosphohydrolase 3;AltName: Full=PAP2-bet

Provider

SWISS-PROT

Sequence

Polypeptide 312 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Plpp3	phospholipid phosphatase 3	109	107	3	68

Sequence references in MGI

J:84753 Escalante-Alcalde D, et al., The lipid phosphatase LPP3 regulates extra-embryonic vasculogenesis and axis patterning. Development. 2003 Oct;130(19):4623-37
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:100643 Humtsoe JO, et al., Murine lipid phosphate phosphohydrolase-3 acts as a cell-associated integrin ligand. Biochem Biophys Res Commun. 2005 Sep 30;335(3):906-19
J:125025 Escalante-Alcalde D, et al., Generation of a conditional Ppap2b/Lpp3 null allele. Genesis. 2007 Jul;45(7):465-9
J:142493 Escalante-Alcalde D, et al., Generation of a reporter-null allele of Ppap2b/Lpp3 and its expression during embryogenesis. Int J Dev Biol. 2009;53(1):139-147
J:169062 Lopez-Juarez A, et al., Expression of LPP3 in Bergmann glia is required for proper cerebellar sphingosine-1-phosphate metabolism/signaling and development. Glia. 2011 Apr;59(4):577-89
J:253292 Chatterjee I, et al., Endothelial lipid phosphate phosphatase-3 deficiency that disrupts the endothelial barrier function is a modifier of cardiovascular development. Cardiovasc Res. 2016 Jul 1;111(1):105-18
J:274308 Federico L, et al., Lipid phosphate phosphatase 3 regulates adipocyte sphingolipid synthesis, but not developmental adipogenesis or diet-induced obesity in mice. PLoS One. 2018;13(6):e0198063
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89