Sequence Detail

ID/Version

Q99J87 Q9D1X4 A2A5E9 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=ATP-dependent RNA helicase DHX58 {ECO:0000250|UniProtKB:Q96C10}; EC=3.6.4.13 {ECO:0000250|UniProtKB:Q96C10};AltName: Full=ATP-dependent helicase LGP2 {ECO:0000250|UniProtKB:Q96C10};AltName: Full=Protein D11Lgp2;AltName: Full=RIG-I-li

Provider

SWISS-PROT

Sequence

Polypeptide 678 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Dhx58	DExH-box helicase 58	62	97	3	16

Sequence references in MGI

J:67577 Miyoshi K, et al., Structure of the mouse stat 3/5 locus: evolution from drosophila to zebrafish to mouse. Genomics. 2001 Jan 15;71(2):150-5
J:73270 Cui Y, et al., The Stat3/5 locus encodes novel endoplasmic reticulum and helicase-like proteins that are preferentially expressed in normal and neoplastic mammary tissue. Genomics. 2001 Dec;78(3):129-34
J:146113 Venkataraman T, et al., Loss of DExD/H box RNA helicase LGP2 manifests disparate antiviral responses. J Immunol. 2007 May 15;178(10):6444-55
J:156867 Satoh T, et al., LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses. Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1512-7
J:172392 Pollpeter D, et al., Impaired Cellular Responses to Cytosolic DNA or Infection with Listeria monocytogenes and Vaccinia Virus in the Absence of the Murine LGP2 Protein. PLoS One. 2011;6(4):e18842
J:183197 Chopy D, et al., Ambivalent role of the innate immune response in rabies virus pathogenesis. J Virol. 2011 Jul;85(13):6657-68
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89