Sequence Detail

ID/Version

Q99J83 (UniProt | EBI)

Last sequence update: 2001-06-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Autophagy protein 5 {ECO:0000305};AltName: Full=APG5-like;

Provider

SWISS-PROT

Sequence

Polypeptide 275 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Atg5	autophagy related 5	133	106	3	32

Sequence references in MGI

J:70539 Mizushima N, et al., Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells. J Cell Biol. 2001 Feb 19;152(4):657-68
J:80842 Mizushima N, et al., Mouse Apg10 as an Apg12-conjugating enzyme: analysis by the conjugation-mediated yeast two-hybrid method. FEBS Lett. 2002 Dec 18;532(3):450-4
J:83346 Mizushima N, et al., Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate. J Cell Sci. 2003 May 1;116(Pt 9):1679-88
J:85938 Nemoto T, et al., The mouse APG10 homologue, an E2-like enzyme for Apg12p conjugation, facilitates MAP-LC3 modification. J Biol Chem. 2003 Oct 10;278(41):39517-26
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:124905 Jounai N, et al., The Atg5 Atg12 conjugate associates with innate antiviral immune responses. Proc Natl Acad Sci U S A. 2007 Aug 28;104(35):14050-5
J:125311 Pua HH, et al., A critical role for the autophagy gene Atg5 in T cell survival and proliferation. J Exp Med. 2007 Jan 22;204(1):25-31
J:150289 Zhang J, et al., Mitochondrial clearance is regulated by Atg7-dependent and -independent mechanisms during reticulocyte maturation. Blood. 2009 Jul 2;114(1):157-64
J:157911 Lee HK, et al., In vivo requirement for Atg5 in antigen presentation by dendritic cells. Immunity. 2010 Feb 26;32(2):227-39
J:168134 Nishiyama J, et al., Aberrant membranes and double-membrane structures accumulate in the axons of Atg5-null Purkinje cells before neuronal death. Autophagy. 2007 Nov-Dec;3(6):591-6
J:203423 Pampliega O, et al., Functional interaction between autophagy and ciliogenesis. Nature. 2013 Oct 10;502(7470):194-200
J:203424 Tang Z, et al., Autophagy promotes primary ciliogenesis by removing OFD1 from centriolar satellites. Nature. 2013 Oct 10;502(7470):254-7
J:215884 Sou YS, et al., The Atg8 conjugation system is indispensable for proper development of autophagic isolation membranes in mice. Mol Biol Cell. 2008 Nov;19(11):4762-75
J:222383 Miller BC, et al., The autophagy gene ATG5 plays an essential role in B lymphocyte development. Autophagy. 2008 Apr;4(3):309-14
J:256127 Okerlund ND, et al., Bassoon Controls Presynaptic Autophagy through Atg5. Neuron. 2017 Feb 22;93(4):897-913.e7
J:289080 Ishibashi K, et al., Atg16L2, a novel isoform of mammalian Atg16L that is not essential for canonical autophagy despite forming an Atg12-5-16L2 complex. Autophagy. 2011 Dec;7(12):1500-13
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:344326 Eguchi T, et al., The V-ATPase-ATG16L1 axis recruits LRRK2 to facilitate the lysosomal stress response. J Cell Biol. 2024 Mar 4;223(3)