Sequence Detail

ID/Version

Q99J79 (UniProt | EBI)

Last sequence update: 2001-06-01
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=DNA damage-binding protein 2;AltName: Full=Damage-specific DNA-binding protein 2;

Provider

SWISS-PROT

Sequence

Polypeptide 432 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ddb2	damage specific DNA binding protein 2	40	96	3	18

Sequence references in MGI

J:61007 Zolezzi F, et al., Studies of the murine DDB1 and DDB2 genes. Gene. 2000 Mar 7;245(1):151-9
J:88125 Itoh T, et al., DDB2 gene disruption leads to skin tumors and resistance to apoptosis after exposure to ultraviolet light but not a chemical carcinogen. Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):2052-7
J:95633 Yoon T, et al., Tumor-prone phenotype of the DDB2-deficient mice. Oncogene. 2005 Jan 13;24(3):469-78
J:125000 Luijsterburg MS, et al., Dynamic in vivo interaction of DDB2 E3 ubiquitin ligase with UV-damaged DNA is independent of damage-recognition protein XPC. J Cell Sci. 2007 Aug 1;120(Pt 15):2706-16
J:125108 Itoh T, et al., Ddb2 is a haploinsufficient tumor suppressor and controls spontaneous germ cell apoptosis. Hum Mol Genet. 2007 Jul 1;16(13):1578-86
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:314115 Zhang Y, et al., USP44 Stabilizes DDB2 to Facilitate Nucleotide Excision Repair and Prevent Tumors. Front Cell Dev Biol. 2021;9:663411